Dispersion of functional gradients across the adult lifespan

被引:115
作者
Bethlehem, Richard A., I [1 ,2 ]
Paquola, Casey [3 ]
Seidlitz, Jakob [4 ,5 ]
Ronan, Lisa [6 ]
Bernhardt, Boris [3 ]
Consortium, Cam-Can [7 ]
Tsvetanov, Kamen A. [8 ,9 ]
机构
[1] Univ Cambridge, Brain Mapping Unit, Dept Psychiat, Cambridge CB2 0SZ, England
[2] Univ Cambridge, Autism Res Ctr, Dept Psychiat, Cambridge, England
[3] McGill Univ, Montreal Neurol Inst & Hosp, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
[4] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA USA
[5] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
[6] Univ Cambridge, Dept Psychiat, Cambridge, England
[7] MRC, Cognit & Brain Sci Unit, Cambridge CB2 7EF, England
[8] Univ Cambridge, Ctr Speech Language & Brain, Dept Psychol, Cambridge CB2 3EB, England
[9] Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 0QQ, England
基金
英国生物技术与生命科学研究理事会; 加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词
INTRINSIC BRAIN; CONNECTIVITY; NETWORKS; FMRI; AGE; CORTEX;
D O I
10.1016/j.neuroimage.2020.117299
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Ageing is commonly associated with changes to segregation and integration of functional brain networks, but, in isolation, current network-based approaches struggle to elucidate changes across the many axes of functional organisation. However, the advent of gradient mapping techniques in neuroimaging provides a new means of studying functional organisation in a multi-dimensional connectivity space. Here, we studied ageing and behaviourally-relevant differences in a three-dimensional connectivity space using the Cambridge Centre for Ageing Neuroscience cohort (n = 643). Building on gradient mapping techniques, we developed a set of measures to quantify the dispersion within and between functional communities. We detected a strong shift of the visual network across the adult lifespan from an extreme to a more central position in the 3D gradient space. In contrast, the dispersion distance between transmodal communities (dorsal attention, ventral attention, frontoparietal and default mode) did not change. However, these communities themselves were increasingly dispersed with increasing age, reflecting more dissimilar functional connectivity profiles within each community. Increasing dispersion of frontoparietal, attention and default mode networks, in particular, were associated negatively with cognition, measured by fluid intelligence. By using a technique that explicitly captures the ordering of functional systems in a multi-dimensional hierarchical framework, we identified behaviorally-relevant age-related differences of within and between network organisation. We propose that the study of functional gradients across the adult lifespan could provide insights that may facilitate the development of new strategies to maintain cognitive ability across the lifespan in health and disease.
引用
收藏
页数:9
相关论文
共 58 条
[1]   On testing for spatial correspondence between maps of human brain structure and function [J].
Alexander-Bloch, Aaron F. ;
Shou, Haochang ;
Liu, Siyuan ;
Satterthwaite, Theodore D. ;
Glahn, David C. ;
Shinohara, Russell T. ;
Vandekar, Simon N. ;
Raznahan, Armin .
NEUROIMAGE, 2018, 178 :540-551
[2]   Disruption of large-scale brain systems in advanced aging [J].
Andrews-Hanna, Jessica R. ;
Snyder, Abraham Z. ;
Vincent, Justin L. ;
Lustig, Cindy ;
Head, Denise ;
Raichle, Marcus E. ;
Buckner, Randy L. .
NEURON, 2007, 56 (05) :924-935
[3]   Using Low-Dimensional Manifolds to Map Relationships Between Dynamic Brain Networks [J].
Bahrami, Mohsen ;
Lyday, Robert G. ;
Casanova, Ramon ;
Burdette, Jonathan H. ;
Simpson, Sean L. ;
Laurienti, Paul J. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2019, 13
[4]   The World Report on Ageing and Health [J].
Beard, John R. ;
Officer, Alana M. ;
Cassels, Andrew K. .
GERONTOLOGIST, 2016, 56 :S163-S166
[5]   Changes in structural and functional connectivity among resting-state networks across the human lifespan [J].
Betzel, Richard F. ;
Byrge, Lisa ;
He, Ye ;
Goni, Joaquin ;
Zuo, Xi-Nian ;
Sporns, Olaf .
NEUROIMAGE, 2014, 102 :345-357
[6]   Echoes of the Brain: Local-Scale Representation of Whole-Brain Functional Networks within Transmodal Cortex [J].
Braga, Rodrigo M. ;
Leech, Robert .
NEUROSCIENTIST, 2015, 21 (05) :540-551
[7]   Perceptual and conceptual processing of visual objects across the adult lifespan [J].
Bruffaerts, Rose ;
Tyler, Lorraine K. ;
Shafto, Meredith ;
Tsvetanov, Kamen A. ;
Clarke, Alex ;
Brayne, Carol ;
Bullmore, Edward T. ;
Calder, Andrew C. ;
Cusack, Rhodri ;
Dalgleish, Tim ;
Duncan, John ;
Henson, Richard N. ;
Matthews, Fiona E. ;
Marslen-Wilson, William D. ;
Rowe, James B. ;
Campbell, Karen ;
Cheung, Teresa ;
Davis, Simon ;
Geerligs, Linda ;
Kievit, Rogier ;
McCarrey, Anna ;
Mustafa, Abdur ;
Price, Darren ;
Samu, David ;
Taylor, Jason R. ;
Treder, Matthias ;
van Belle, Janna ;
Williams, Nitin ;
Bates, Lauren ;
Emery, Tina ;
Erzinclioglu, Sharon ;
Gadie, Andrew ;
Gerbase, Sofia ;
Georgieva, Stanimira ;
Hanley, Claire ;
Parkin, Beth ;
Troy, David ;
Auer, Tibor ;
Correia, Marta ;
Gao, Lu ;
Green, Emma ;
Henriques, Rafael ;
Allen, Jodie ;
Amery, Gillian ;
Amunts, Liana ;
Barcroft, Anne ;
Castle, Amanda ;
Dias, Cheryl ;
Dowrick, Jonathan ;
Fair, Melissa .
SCIENTIFIC REPORTS, 2019, 9 (1)
[8]   THEORY OF FLUID AND CRYSTALLIZED INTELLIGENCE - A CRITICAL EXPERIMENT [J].
CATTELL, RB .
JOURNAL OF EDUCATIONAL PSYCHOLOGY, 1963, 54 (01) :1-22
[9]   Decreased segregation of brain systems across the healthy adult lifespan [J].
Chan, Micaela Y. ;
Park, Denise C. ;
Savalia, Neil K. ;
Petersen, Steven E. ;
Wig, Gagan S. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (46) :E4997-E5006
[10]   Diffusion maps [J].
Coifman, Ronald R. ;
Lafon, Stephane .
APPLIED AND COMPUTATIONAL HARMONIC ANALYSIS, 2006, 21 (01) :5-30