Maximal diameter of liver abscess independently predicts prolonged hospitalization and poor prognosis in patients with pyogenic liver abscess

被引：33

作者：

Lee, Chang Hun ^{[1
,2
]}

Jo, Hoon Gil ^{[3
]}

Cho, Eun Young ^{[3
]}

Song, Jae Sun ^{[4
]}

Jung, Gum Mo ^{[4
]}

Cho, Yong Keun ^{[4
]}

Seo, Seung Young ^{[1
,2
]}

Kim, Seong Hun ^{[1
,2
]}

Kim, Sang Wook ^{[1
,2
]}

Lee, Seung Ok ^{[1
,2
]}

Lee, Soo Teik ^{[1
,2
]}

Kim, In Hee ^{[1
,2
]}

机构：

[1] Jeonbuk Natl Univ, Div Gastroenterol, Dept Internal Med, Sch Med, 20 Geonjiro, Jeonju 54907, Jeonbuk, South Korea

[2] Jeonbuk Natl Univ, Res Inst Clin Med, Jeonbuk Natl Univ Hosp, Sch Med, 20 Geonjiro, Jeonju 54907, Jeonbuk, South Korea

[3] Wonkwang Univ, Div Gastroenterol, Dept Internal Med, Coll Med & Hosp, Iksan, South Korea

[4] Presbyterian Med Ctr, Div Gastroenterol, Dept Internal Med, Jeonju, South Korea

来源：

BMC INFECTIOUS DISEASES | 2021年 / 21卷 / 01期

关键词：

Liver abscess; pyogenic; Hospitalization; Mortality; in-hospital;

D O I：

10.1186/s12879-021-05873-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background/aims This study aimed to investigate the factors associated with prolonged hospital stay and in-hospital mortality in patients with pyogenic liver abscess. Methods We retrospectively reviewed data from patients with pyogenic liver abscess who were admitted between 2005 and 2018 at three tertiary hospitals in Jeonbuk province, South Korea. Prolonged hospital stay was defined as a duration of hospital admission of more than 21 days. Results A total of 648 patients (406 men and 242 women) diagnosed with pyogenic liver abscess were enrolled in the study. The mean maximal diameter of the liver abscess was 5.4 +/- 2.6 cm, and 74.9% of the lesions were single. The three groups were divided according to the maximal diameter of the abscess. Laboratory parameters indicated a more severe inflammatory state and higher incidence of complications and extrahepatic manifestations with increasing abscess size. Rates of percutaneous catheter drainage (PCD) insertion, multiple PCD drainage, and salvage procedures as well as duration of drainage were also higher in the large liver abscess group. Of note, the duration of hospitalization and in-hospital mortality were significantly higher in the large hepatic abscess group. A multivariate analysis revealed that underlying diabetes mellitus, hypoalbuminemia, high baseline high-sensitivity C-reactive protein (hs-CRP) and procalcitonin levels, and large maximal abscess diameter were independent factors associated with prolonged hospital stay. Regarding in-hospital mortality, acute kidney injury at admission and maximal diameter of the abscess were independent factors associated with in-hospital mortality. Conclusions A large maximal diameter of the liver abscess at admission indicated prolonged hospitalization and poor prognosis. More aggressive treatment strategies with careful monitoring are warranted in patients with large liver abscesses.

引用

页数：10

共 32 条

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