Cytokines, Atherogenesis, and Hypercatabolism in Chronic Kidney Disease: A Dreadful Triad

被引:65
作者
Carrero, Juan Jesus
Park, Sun-Hee
Axelsson, Jonas
Lindholm, Bengt
Stenvinkel, Peter
机构
[1] Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
[2] Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
基金
英国医学研究理事会;
关键词
BETA-CHEMOKINE LEVELS; NECROSIS-FACTOR-ALPHA; DIALYSIS PATIENTS; HEMODIALYSIS-PATIENTS; MESSENGER-RNA; RHEUMATOID-ARTHRITIS; PERITONEAL-DIALYSIS; PEDIATRIC-PATIENTS; RANDOMIZED-TRIAL; UREMIC PATIENTS;
D O I
10.1111/j.1525-139X.2009.00585.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The term cytokine clusters denotes a copious family of molecules and correspondent receptors implicated in numerous processes mediating health and disease. In the context of chronic kidney disease (CKD), generation and metabolism of most of these cytokines are disturbed. Available evidence suggests that cytokine imbalances contribute to the progression of common CKD complications, such as atherosclerosis, mineral-bone disease, and protein-energy wasting via pleiotropic effects. The belief that cytokine CKD research is solely represented by interleukins (IL) and tumor-necrosis factors (TNF) (mainly IL-6 and TNF-alpha) is a common misconception among nephrologists. We here explore recent findings concerning the pathophysiological role of various cytokines in uremic complications, and discuss how cytokines could be used as novel potential therapeutic targets in CKD. At the same time, we provide a brief overview of current discoveries in the main transforming growth factors and chemokines.
引用
收藏
页码:381 / 386
页数:6
相关论文
共 44 条
[1]   A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation [J].
Anders, HJ ;
Vielhauer, V ;
Frink, M ;
Linde, Y ;
Cohen, CD ;
Blattner, SM ;
Kretzler, M ;
Strutz, F ;
Mack, M ;
Gröne, HJ ;
Onuffer, J ;
Horuk, R ;
Nelson, PJ ;
Schlöndorff, D .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (02) :251-259
[2]   Pentoxifylline acutely reduces protein catabolism in chronically uremic patients [J].
Biolo, G ;
Ciocchi, B ;
Bosutti, A ;
Situlin, R ;
Toigo, G ;
Guarnieri, G .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 40 (06) :1162-1172
[3]   Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans [J].
Bruun, JM ;
Lihn, AS ;
Verdich, C ;
Pedersen, SB ;
Toubro, S ;
Astrup, A ;
Richelsen, B .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2003, 285 (03) :E527-E533
[4]   Inflammatory signals associated with hemodialysis [J].
Caglar, K ;
Peng, Y ;
Pupim, LB ;
Flakoll, PJ ;
Levenhagen, D ;
Hakim, RM ;
Ikizler, TA .
KIDNEY INTERNATIONAL, 2002, 62 (04) :1408-1416
[5]   Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease [J].
Carrero, J. J. ;
Qureshi, A. R. ;
Axelsson, J. ;
Yilmaz, M. I. ;
Rehnmark, S. ;
Witt, M. R. ;
Barany, P. ;
Heimburger, O. ;
Suliman, M. E. ;
Alvestrand, A. ;
Lindholm, B. ;
Stenvinkel, P. .
JOURNAL OF INTERNAL MEDICINE, 2007, 262 (06) :690-701
[6]   Additive Effects of Soluble TWEAK and Inflammation on Mortality in Hemodialysis Patients [J].
Carrero, Juan J. ;
Ortiz, Alberto ;
Qureshi, Abdul R. ;
Martin-Ventura, Jose L. ;
Barany, Peter ;
Heimburger, Olof ;
Marron, Belen ;
Metry, George ;
Snaedal, Sunna ;
Lindholm, Bengt ;
Egido, Jesus ;
Stenvinkel, Peter ;
Blanco-Colio, Luis M. .
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 4 (01) :110-118
[7]   Muscle atrophy, inflammation and clinical outcome in incident and prevalent dialysis patients [J].
Carrero, Juan Jesus ;
Chmielewski, Michal ;
Axelsson, Jonas ;
Snaedal, Sunna ;
Heimburger, Olof ;
Barany, Peter ;
Suliman, Mohamed E. ;
Lindholm, Bengt ;
Stenvinkel, Peter ;
Qureshi, Abdul Rashid .
CLINICAL NUTRITION, 2008, 27 (04) :557-564
[8]   Cytokine dysregulation in chronic kidney disease: How can we treat it? [J].
Carrero, Juan Jesus ;
Yilmaz, Mahmut Ilker ;
Lindholm, Bengt ;
Stenvinkel, Peter .
BLOOD PURIFICATION, 2008, 26 (03) :291-299
[9]   Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetites [J].
Carrero, Juan Jesus ;
Qureshi, Abdul Rashid ;
Axelsson, Jonas ;
Avesani, Carla Maria ;
Suliman, Mohammed E. ;
Kato, Sawako ;
Barany, Peter ;
Snaedal-Jonsdottir, Sunna ;
Alvestrand, Anders ;
Heimburger, Olof ;
Lindholm, Bengt ;
Stenvinkel, Peter .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (03) :695-701
[10]   Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients [J].
Carrero, Juan Jesus ;
Qureshi, Abdul Rashid ;
Parini, Paolo ;
Arver, Stefan ;
Lindholm, Bengt ;
Barany, Peter ;
Heimburger, Olof ;
Stenvinkel, Peter .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2009, 20 (03) :613-620