Transformative tools for tackling tuberculosis

被引：32

作者：

Gardiner, Jennifer L. ^{[1
]}

Karp, Christopher L. ^{[1
]}

机构：

[1] Global Hlth Bill & Melinda Gates Fdn, Discovery & Translat Sci, Seattle, WA 98102 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2015年 / 212卷 / 11期

关键词：

ISONIAZID PREVENTIVE THERAPY; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; ACTIVE TUBERCULOSIS; BCG VACCINATION; XPERT MTB/RIF; CYNOMOLGUS MACAQUES; LATENT TUBERCULOSIS; T-CELLS; INFECTION;

D O I：

10.1084/jem.20151468

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The world is in need of more effective approaches to controlling tuberculosis. The development of improved control strategies has been hampered by deficiencies in the tools available for detecting Mycobacterium tuberculosis and defining the dynamic consequences of the interaction of M. tuberculosis with its human host. Key needs include a highly sensitive, specific nonsputum diagnostic; biomarkers predictive of responses to therapy; correlates of risk for disease development; and host response-independent markers of M. tuberculosis infection. Tools able to sensitively detect and quantify total body M. tuberculosis burden might well be transformative across many needed use cases. Here, we review the current state of the field, paying particular attention to needed changes in experimental paradigms that would facilitate the discovery, validation, and development of such tools.

引用

页码：1759 / 1769

页数：11

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