Cell kinetics and cell cycle regulation in lymphomas

被引：16
作者：
Leoncini, L [1 ]
Lazzi, S [1 ]
Bellan, C [1 ]
Tosi, P [1 ]
机构：
[1] Univ Siena, Inst Pathol Anat & Histol, I-53100 Siena, Italy
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2002年 / 55卷 / 09期
关键词：
D O I：
10.1136/jcp.55.9.648
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas.
引用
收藏
页码：648 / 655
页数：8
相关论文
共 114 条
  • [91] Role of the cyclin-dependent kinase 4 and 6 inhibitor gene family p15, p16, p18 and p19 in leukemia and lymphoma
    Siebert, R
    Willers, CP
    Opalka, B
    [J]. LEUKEMIA & LYMPHOMA, 1996, 23 (5-6) : 505 - &
  • [92] Sola B, 1999, INT J CANCER, V83, P230, DOI 10.1002/(SICI)1097-0215(19991008)83:2<230::AID-IJC14>3.0.CO
  • [93] 2-J
  • [94] Spina D, 1997, J PATHOL, V182, P145, DOI 10.1002/(SICI)1096-9896(199706)182:2<145::AID-PATH819>3.0.CO
  • [95] 2-P
  • [96] LOW VERSUS HIGH CELL TURNOVER IN DIFFUSELY GROWING NON-HODGKINS-LYMPHOMAS
    SPINA, D
    LEONCINI, L
    DELVECCHIO, MT
    MEGHA, T
    MINACCI, C
    POGGI, SA
    PILERI, S
    TOSI, P
    KRAFT, R
    LAISSUE, JA
    COTTIER, H
    [J]. JOURNAL OF PATHOLOGY, 1995, 177 (04) : 335 - 341
  • [97] Spina D, 1997, INT J CANCER, V73, P178, DOI 10.1002/(SICI)1097-0215(19971009)73:2<178::AID-IJC2>3.0.CO
  • [98] 2-T
  • [99] SPINA D, 1996, INT J CANCER, V65, P1
  • [100] STEIN GS, 1999, MOL BASIS CELL CYCLE
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