MRI-visible perivascular spaces are associated with cerebrospinal fluid biomarkers in Parkinson's disease

被引：21

作者：

Fang, Yi ^{[1
]}

Gu, Lu-Yan ^{[1
]}

Tian, Jun ^{[1
]}

Dai, Shao-Bing ^{[2
]}

Chen, Ying ^{[1
]}

Zheng, Ran ^{[1
]}

Si, Xiao-Li ^{[1
,3
]}

Jin, Chong-Yao ^{[1
]}

Song, Zhe ^{[1
]}

Yan, Ya-Ping ^{[1
]}

Yin, Xin-Zhen ^{[1
]}

Pu, Jia-Li ^{[1
]}

Zhang, Bao-Rong ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurol, Hangzhou 310009, Zhejiang, Peoples R China

[2] Zhejiang Univ, Womens Hosp, Sch Med, Dept Anesthesiol, Hangzhou 310009, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sch Med, Dept Neurol, Affiliated Hangzhou First Peoples Hosp, Hangzhou 310006, Zhejiang, Peoples R China

来源：

AGING-US | 2020年 / 12卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; alpha-synuclein; brain perivascular space; glymphatic system; VIRCHOW-ROBIN SPACES; SMALL VESSEL DISEASE; ALPHA-SYNUCLEIN; BASAL GANGLIA; POSTERIOR CONNECTIVITY; COGNITIVE FUNCTION; DYSFUNCTION; DEMENTIA; RISK;

D O I：

10.18632/aging.104200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Perivascular spaces in the brain have been known to communicate with cerebrospinal fluid and contribute to waste clearance in animal models. In this study, we sought to determine the association between MRI-visible enlarged perivascular spaces (EPVS) and disease markers in Parkinson's disease (PD). We obtained longitudinal data from 245 patients with PD and 98 healthy controls from the Parkinson's Progression Marker Initiative. Two trained neurologists performed visual ratings on T2-weighted images to characterize EPVS in the centrum semiovale (CSO), the basal ganglia (BG) and the midbrain. We found that a greater proportion of patients with PD had low grade BG-EPVS relative to healthy controls. In patients with PD, lower grade of BG-EPVS and CSO-EPVS predicted lower CSF alpha-synuclein and t-tau. Lower grade of BG-EPVS were also associated with accelerated Hoehn &Yahr stage progression in patients with baseline stage 1. BG-EPVS might be a valuable predictor of disease progression.

引用

页码：25805 / 25818

页数：14

共 47 条

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