共 56 条
-765G>CCOX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia
被引:49
作者:

Pereira, Carina
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Sousa, Hugo
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Ferreira, Paula
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Fragoso, Maria
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Moreira-Dias, Luis
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Lopes, Carlos
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Medeiros, Rui
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal

Dinis-Ribeiro, Mario
论文数: 0 引用数: 0
h-index: 0
机构: Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal
机构:
[1] Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal
[2] Portuguese Inst Oncol Porto, Dept Oncol, Oporto, Portugal
[3] Portuguese Inst Oncol Porto, Dept Gastroenterol, Oporto, Portugal
[4] Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal
[5] Abel Salazar Inst Biomed Sci, Oporto, Portugal
[6] Univ Porto, Fac Med, P-4100 Oporto, Portugal
关键词:
gastric adenocarcinoma;
atrophy;
intestinal metaplasia;
COX-2;
polymorphism;
PCR-RFLP;
pharmacogenomic;
D O I:
10.3748/wjg.v12.i34.5473
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04). CONCLUSION: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. (C) 2006 The WJG Press. All rights reserved.
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页码:5473 / 5478
页数:6
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