-765G>CCOX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia

被引:49
作者
Pereira, Carina
Sousa, Hugo
Ferreira, Paula
Fragoso, Maria
Moreira-Dias, Luis
Lopes, Carlos
Medeiros, Rui
Dinis-Ribeiro, Mario
机构
[1] Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal
[2] Portuguese Inst Oncol Porto, Dept Oncol, Oporto, Portugal
[3] Portuguese Inst Oncol Porto, Dept Gastroenterol, Oporto, Portugal
[4] Portuguese Inst Oncol Porto, Mol Oncol Grp, Oporto, Portugal
[5] Abel Salazar Inst Biomed Sci, Oporto, Portugal
[6] Univ Porto, Fac Med, P-4100 Oporto, Portugal
关键词
gastric adenocarcinoma; atrophy; intestinal metaplasia; COX-2; polymorphism; PCR-RFLP; pharmacogenomic;
D O I
10.3748/wjg.v12.i34.5473
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04). CONCLUSION: -765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. (C) 2006 The WJG Press. All rights reserved.
引用
收藏
页码:5473 / 5478
页数:6
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