Genomic Approaches to Problems in Pituitary Neoplasia

被引：7

作者：

Asa, Sylvia L. ^{[1
,3
]}

Ezzat, Shereen ^{[2
,4
]}

机构：

[1] Univ Hlth Network, Dept Pathol, Toronto, ON M5G 2C4, Canada

[2] Univ Hlth Network, Dept Med, Toronto, ON M5G 2C4, Canada

[3] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, Dept Med, Toronto, ON, Canada

来源：

ENDOCRINE PATHOLOGY | 2014年 / 25卷 / 03期

关键词：

Pituitary; Neoplasia; Genomics; Epigenetics; TRANSCRIPTION FACTOR IKAROS; GROWTH-INHIBITORY GENE; TUMOR-SUPPRESSOR GENE; RETINOBLASTOMA GENE; GERMLINE MUTATIONS; MICE LACKING; EXPRESSION; ADENOMAS; ENDOCRINE; P27(KIP1);

D O I：

10.1007/s12022-013-9276-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The genetic mutations underlying familial syndromes that include pituitary tumors are rarely noted in the majority of sporadic adenohypophyseal adenomas. In contrast, epigenetic dysregulation is common, resulting in differential expression of cell cycle and apoptosis regulators, adhesion molecules, growth factors, and metabolic determinants of cell function. Here, we discuss the diagnostic and therapeutic implications of these findings as the landscape of pituitary tumor defects unfolds.

引用

页码：209 / 213

页数：5

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