MicroRNA Signature in Renal Cell Carcinoma

被引：34
作者：
Ghafouri-Fard, Soudeh [1 ]
Shirvani-Farsani, Zeinab [2 ]
Branicki, Wojciech [3 ]
Taheri, Mohammad [4 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
[2] Shahid Beheshti Univ, GC, Fac Life Sci & Technol, Dept Cell & Mol Biol, Tehran, Iran
[3] Jagiellonian Univ, Malopolska Ctr Biotechnol, Krakow, Poland
[4] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran
来源：
FRONTIERS IN ONCOLOGY | 2020年 / 10卷
关键词：
miRNA; renal cell carcinoma; expression; cancer; biomarker; DOWN-REGULATION; PROGNOSTIC MARKER; MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; POOR-PROGNOSIS; UP-REGULATION; TARGET GENES; PROLIFERATION; INVASION; METASTASIS;
D O I：
10.3389/fonc.2020.596359
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Renal cell carcinoma (RCC) includes 2.2% of all diagnosed cancers and 1.8% of cancer-related mortalities. The available biomarkers or screening methods for RCC suffer from lack of sensitivity or high cost, necessitating identification of novel biomarkers that facilitate early diagnosis of this cancer especially in the susceptible individuals. MicroRNAs (miRNAs) have several advantageous properties that potentiate them as biomarkers for cancer detection. Expression profile of miRNAs has been assessed in biological samples from RCC patients. Circulatory or urinary levels of certain miRNAs have been proposed as markers for RCC diagnosis or follow-up. Moreover, expression profile of some miRNAs has been correlated with response to chemotherapy, immunotherapy or targeted therapeutic options such as sunitinib. In the current study, we summarize the results of studies that assessed the application of miRNAs as biomarkers, therapeutic targets or modulators of response to treatment modalities in RCC patients.
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页数：16
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