Lipid-Modifying Treatments for Heart Failure: Is Their Use Justified?

被引：5

作者：

Cleland, John G. F. ^{[1
,2
]}

Hutchinson, Kate ^{[3
]}

Pellicori, Pierpaolo ^{[3
]}

Clark, Andrew ^{[3
]}

机构：

[1] Imperial Coll, Royal Brompton Hosp, Natl Heart & Lung Inst, Harefield UB9 6JH, Middx, England

[2] Imperial Coll, Harefield Hosp, Natl Heart & Lung Inst, Harefield UB9 6JH, Middx, England

[3] Castle Hill Hosp, Hull York Med Sch, Dept Cardiol, Kingston Upon Hull HU6 5JQ, Yorks, England

来源：

HEART FAILURE CLINICS | 2014年 / 10卷 / 04期

关键词：

Fibrates; Polyunsaturated fatty acids; Statins; Heart failure; POLYUNSATURATED FATTY-ACIDS; GISSI-HF TRIAL; NATRIURETIC PEPTIDE; STATIN THERAPY; SUDDEN-DEATH; DOUBLE-BLIND; TASK-FORCE; ATORVASTATIN; ROSUVASTATIN; ASSOCIATION;

D O I：

10.1016/j.hfc.2014.07.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interventions for coronary artery disease in heart failure have not been successful. It seems unlikely that coronary events play no role in the progression of heart failure and the ultimate demise of the patient. Meta-analysis suggests no benefit of fibrates in cardiovascular disease or heart failure. Polyunsaturated fats have equal benefit in cardiovascular disease. Two large trials of statins found no effect on mortality, but one trial found a reduction in morbidity. Retrospective analyses suggest that patients with milder disease might retain the benefit observed with statins in patients with coronary disease who do not have heart failure. Differences among statins may exist.

引用

页码：621 / +

页数：16

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