Performance of mice in an automated olfactometer: Odor detection, discrimination and odor memory

被引:169
作者
Bodyak, N [1 ]
Slotnick, B [1 ]
机构
[1] American Univ, Dept Psychol, Washington, DC 20016 USA
关键词
D O I
10.1093/chemse/24.6.637
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Mice were trained on a variety of odor detection and discrimination lash in 100- or 200-trial sessions using a go, no-go discrete trials operant conditioning procedure. Odors, presented for 1 s on each trial, were generated by an air dilution olfactometer (for threshold tests) and an easily constructed eight-channel liquid dilution unit (for two- and multiple-odor discrimination tasks). Mice rapidly acquired the operant task and demonstrated excellent stimulus control by odor vapors. Their absolute detection threshold for ethyl acetate was similar to that obtained with rats using similar methods. They readily acquired four separate two-odor discrimination tasks and continued to perform well when all eight odors were presented in random order in the same session and when reinforcement probability for correct responding was decreased from 1 to 0.5. Memory for these eight odors, assessed under extinction after a 3t day rest period, was essentially perfect. Time spent sampling the odor on S+ and S- trials was highly correlated with response accuracy When accuracy was at chance levels (e.g. initial trials on a novel task), stimulus sampling time on both S+ and S- trials was similar to 0.5-0.7 s. As response accuracy increased, sampling time on S+ trials tended to increase and remain higher than sampling time on S- trials.
引用
收藏
页码:637 / 645
页数:9
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