Reconciliation of pH, conductivity, total organic carbon with carboxylic acids detected by ion chromatography in solution after contact with multilayer films after γ-irradiation

被引：16

作者：

Dorey, Samuel ^{[1
]}

Gaston, Fanny ^{[1
,2
,3
]}

Dupuy, Nathalie ^{[2
]}

Barbaroux, Magali ^{[1
]}

Marque, Sylvain R. A. ^{[3
,4
]}

机构：

[1] Sartorius Stedim FMT SAS, ZI Les Paluds, Ave Jouques CS91051, F-13781 Aubagne, France

[2] Aix Marseille Univ, Avignon Univ, CNRS, IRD,IMBE UMR 7263, F-13397 Marseille, France

[3] Aix Marseille Univ, CNRS, ICR, Case 551, F-13397 Marseille, France

[4] Vorozhtsov Novosibirsk Inst Organ Chem, Off 312, 9 Prospect Acad Laurentiev, Novosibirsk 630090, Russia

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 117卷

关键词：

gamma-Irradiation; Polyethylene; Ethylene vinyl acetate; Ion chromatography; Carboxylic acid; PK(A) VALUES; POLYETHYLENE; DEGRADATION; FORMULAS; FTIR;

D O I：

10.1016/j.ejps.2018.02.023

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The impact of gamma-irradiation on polymers in multilayer films was studied by means of the study of the diffusion and release (spontaneous migration of the molecules from the container into the product) of chemical species in aqueous solution. A series of different measurements have been performed: pH, conductivity, total organic carbon (TOC) and ion chromatography (IC). Their evolution according to gamma-irradiation dose was studied. More several rinsings made over several months allowed to quantify well the impact of the irradiation on these polymers. The samples are irradiated at several gamma-doses, up to 270 kGy, and compared with a non-irradiated sample used as reference. It shows that quantity of generated carboxylic acids depends on the film material (PE/EVOH/PE and EVA/EVOH/EVA) and increases with gamma-dose.

引用

页码：216 / 226

页数：11

共 32 条

[1]

[Anonymous], GUID IRR STER VAL SI, P12

[2]

[Anonymous], 2002, PRACTICE INTRO MULTI

[3] Degradation of γ-irradiated polyethylene-ethylene vinyl alcoholpolyethylene multilayer films: An ESR study [J].

Audran, Gerard ;

Dorey, Samuel ;

Dupuy, Nathalie ;

Gaston, Fanny ;

Marque, Sylvain R. A. .

POLYMER DEGRADATION AND STABILITY, 2015, 122 :169-179

[4]

CARDINALI ME, 1995, B SOC CHIM BELG, V104, P7

[5] A NEW METHOD FOR THE PH CALCULATION OF SOLUTIONS AND MIXTURES OF ACIDS, BASES AND SALTS [J].

CLAEYS, AE .

ANALYTICA CHIMICA ACTA, 1985, 178 (02) :277-288

[6]

Da Silva Aquino K. A., 2012, STERILIZATION GAMMA

[7]

Demertzis PG, 1999, PACKAG TECHNOL SCI, V12, P119, DOI 10.1002/(SICI)1099-1522(199905/06)12:3<119::AID-PTS460>3.0.CO

[8]

2-G

[9] XPS analysis of PE and EVA samples irradiated at different γ-doses [J].

Dorey, Samuel ;

Gaston, Fanny ;

Marque, Sylvain R. A. ;

Bortolotti, Benjamin ;

Dupuy, Nathalie .

APPLIED SURFACE SCIENCE, 2018, 427 :966-972

[10]

Driffield M., 2009, LIT REV ANAL SCREENI

← 1 2 3 4 →