HBV Infection and Hepatocellular Carcinoma

被引：36

作者：

Iavarone, Massimo ^{[1
]}

Colombo, Massimo ^{[1
]}

机构：

[1] Univ Milan, Fdn IRCCS Ca Granda Maggiore Hosp, Div Gastroenterol 1, AM & A Migliavacca Ctr Liver Dis, I-20122 Milan, Italy

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 03期

关键词：

Hepatitis B; Hepatocellular carcinoma; Interferon; Nucleos(t)ide analogues; Surveillance; HEPATITIS-B-VIRUS; PRIMARY LIVER-CANCER; C VIRAL-INFECTION; INTRAHEPATIC RECURRENCE; PROSPECTIVE VALIDATION; INTERFERON TREATMENT; CIRRHOTIC-PATIENTS; RISK-FACTORS; SURVEILLANCE; METAANALYSIS;

D O I：

10.1016/j.cld.2013.05.002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The hepatitis B virus (HBV) plays a dominant role in the 749,000 new cases and 692,000 deaths related to hepatocellular carcinoma (HCC) that are estimated to occur each year worldwide. Chronic infection with HBV is responsible for 60% of HCCs in Asia and Africa and at least 20% of the tumors in Europe, Japan, and the United States. This article discusses the pathogenic role of HBV and the risk of HCC. Tumors almost invariably develop in the context of chronic hepatitis or cirrhosis, which makes early diagnosis the only practical approach to improve prognosis. The treatment options are also discussed.

引用

页码：375 / +

页数：24

共 89 条

[1] PRIMARY CARCINOMA OF LIVER - STUDY OF 282 CASES IN UGANDAN AFRICANS [J].

ANTHONY, PP .

JOURNAL OF PATHOLOGY, 1973, 110 (01) :37-&

[2]

BEASLEY RP, 1981, LANCET, V2, P1129

[3] Hepatitis B Virus X Protein: Molecular Functions and Its Role in Virus Life Cycle and Pathogenesis [J].

Benhenda, Shirine ;

Cougot, Delphine ;

Buendia, Marie-Annick ;

Neuveut, Christine .

ADVANCES IN CANCER RESEARCH, VOL 103, 2009, 103 :75-+

[4] Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets [J].

Boyault, Sandrine ;

Rickman, David S. ;

de Reynies, Aurelien ;

Balabaud, Charles ;

Rebouissou, Sandra ;

Jeannot, Emmanuelle ;

Herault, Aurelie ;

Saric, Jean ;

Belghiti, Jacques ;

Franco, Dominique ;

Bioulac-Sage, Paulette ;

Laurent-Puig, Pierre ;

Zucman-Rossi, Jessica .

HEPATOLOGY, 2007, 45 (01) :42-52

[5] Pathogenesis of hepatitis B virus-related hepatocellular carcinoma:: Old and new paradigms [J].

Bréchot, C .

GASTROENTEROLOGY, 2004, 127 (05) :S56-S61

[6] Surgical resection of hepatocellular carcinoma in cirrhotic patients: Prognostic value of preoperative portal pressure [J].

Bruix, J ;

Castells, A ;

Bosch, J ;

Feu, F ;

Fuster, J ;

GarciaPagan, JC ;

Visa, J ;

Bru, C ;

Rodes, J .

GASTROENTEROLOGY, 1996, 111 (04) :1018-1022

[7] Clinical management of hepatocellular carcinoma.: Conclusions of the Barcelona-2000 EASL Conference [J].

Bruix, J ;

Sherman, M ;

Llovet, JM ;

Beaugrand, M ;

Lencioni, R ;

Burroughs, AK ;

Christensen, E ;

Pagliaro, L ;

Colombo, M ;

Rodés, J .

JOURNAL OF HEPATOLOGY, 2001, 35 (03) :421-430

[8] Management of Hepatocellular Carcinoma: An Update [J].

Bruix, Jordi ;

Sherman, Morris .

HEPATOLOGY, 2011, 53 (03) :1020-1022

[9] Interferon and prevention of hepatocellular carcinoma in viral cirrhosis:: an evidence-based approach [J].

Cammà, C ;

Giunta, M ;

Andreone, P ;

Craxì, A .

JOURNAL OF HEPATOLOGY, 2001, 34 (04) :593-602

[10] Nuclear-Targeted Deleted in Liver Cancer 1 (DLC1) Is Less Efficient in Exerting Its Tumor Suppressive Activity Both In Vitro and In Vivo [J].

Chan, Lo-Kong ;

Ko, Frankie Chi Fat ;

Sze, Karen Man-Fong ;

Ng, Irene Oi-Lin ;

Yam, Judy Wai Ping .

PLOS ONE, 2011, 6 (09)

← 1 2 3 4 5 6 7 8 9 →