(-)-Nakadomarin A is an alkaloid belongs to manzamine family having architecturally complex structure and exhibits promising biological activities. To accomplish this target molecule, few novel synthetic strategies have been developed by eminent synthetic chemists. This review will highlight the important and improved synthetic approaches for the total synthesis of natural as well as unnatural isomers of nakadomarin A. All synthetic strategies have been enlightened from the cluster of literatures to develop a more elegant strategy for the molecule in future.
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Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, IranUniv Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran
Karimian, Somaye
Larijani, Bagher
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Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, IranUniv Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran
Larijani, Bagher
Mahdavi, Mohammad
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Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, IranUniv Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran