Virus Impact on Lipids and Membranes

被引:86
作者
Ketter, Ellen [1 ]
Randall, Glenn [1 ]
机构
[1] Univ Chicago, Dept Microbiol, Chicago, IL 60637 USA
来源
ANNUAL REVIEW OF VIROLOGY, VOL 6, 2019 | 2019年 / 6卷
关键词
lipids; membrane; metabolism; replication compartments; envelopment; HEPATITIS-C VIRUS; FATTY-ACID SYNTHASE; STRAND RNA VIRUSES; 4-KINASE III ALPHA; WEST NILE; VIRAL REPLICATION; PROTEIN; CHOLESTEROL; INFECTION; COMPLEX;
D O I
10.1146/annurev-virology-092818-015748
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes during endocytosis, the reorganization of cellular membranes to form replication compartments, and the envelopment and egress of virions. In addition to the physical interactions with cellular membranes, viruses have evolved to manipulate lipid signaling and metabolism to benefit their replication. This review summarizes the strategies that viruses use to manipulate lipids and membranes at each stage in the viral life cycle.
引用
收藏
页码:319 / 340
页数:22
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