Botulinum Toxin A with Fissurectomy Is a Viable Alternative to Lateral Internal Sphincterotomy for Chronic Anal Fissure

被引:5
作者
Aivaz, Ohara [1 ]
Rayhanabad, Jessica [1 ]
Nguyen, Vincent [1 ]
Haigh, Philip I. [1 ]
Abbas, Maher [1 ]
机构
[1] Kaiser Permanente, Ctr Minimally Invas Surg, Dept Surg, Los Angeles, CA 90027 USA
关键词
GLYCERYL TRINITRATE; FECAL INCONTINENCE; TOPICAL NIFEDIPINE; CONTROLLED-TRIAL; FOLLOW-UP; IN-ANO; INJECTION; OINTMENT; NITROGLYCERIN;
D O I
暂无
中图分类号
R61 [外科手术学];
学科分类号
摘要
Lateral internal sphincterotomy (LIS) is the gold standard surgical treatment for anal fissure. However, it carries potential complications, including fecal incontinence. The goal of this retrospective study was to compare the outcome of botulinum toxin A injection coupled with fissurectomy ([BTX + FIS) versus LIS. There were 59 patients who underwent BTX + FIS or LIS over a 5-year period. LIS was performed in the standard fashion without fissurectomy. BTX + FIS entailed internal sphincter injection with 80 units of botulinum toxin A coupled with fissurectomy. Forty patients underwent LIS and 19 had BTX + FIS. The choice of operation was based on the patient's preference. Primary healing rate was 90 and 74 per cent in the LIS and BTX + FIS groups, respectively (P = 0.13). The complication rate was 10 per cent in the LIS vs 0 per cent in the BTX + FIS groups (P = 0.29). Complications of LIS included anal sepsis in one patient and flatal and/or fecal incontinence in three patients. During a mean follow up of 19 months; recurrence rate was 0 and 5 per cent in the LIS and BTX+FIS groups, respectively (P = 0.32). The results of this study demonstrate that BTX + FIS is a viable alternative to LIS for patients with chronic anal fissure and should be considered as an alternative first-line surgical therapy.
引用
收藏
页码:925 / 928
页数:4
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