Four-component tandem protocol for the stereoselective synthesis of highly functionalized [1,4]-thiazines

被引：36

作者：

Indumathi, Sethuraman ^{[1
]}

Kumar, Raju Ranjith ^{[1
]}

Perumal, Subbu ^{[1
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

来源：

TETRAHEDRON | 2007年 / 63卷 / 06期

关键词：

pyrrolothiazine; pyrrolidine; stereoselectivity; tandem;

D O I：

10.1016/j.tet.2006.11.093

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The one-pot, four-component tandem reaction of ethyl 2-[(2-oxo-2-arylethyl)sulfonyl]acetate/ethyl 2+2-ethoxy-2-oxoethyl)sulfonyl] acetate, an aromatic aldehyde and pyrrolidine provides a rapid and facile access to new ethyl 3-aroyl-l-benzyl-2,2-dioxo-4aryloctahydro-2-pyrrolo[2,1-c][1,4]thiazine-l-carboxylates/diethyl 1-benzyl-2,2-dioxo-4-aryloctahydro-2-pyrrolo[2,1-c][1,4]thiazine-1,3dicarboxylates. This reaction shows high stereoselectivity and proceeds in good yields. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1411 / 1416

页数：6

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