Allogeneic haematopoietic stem cell transplantation: individualized stem cell and immune therapy of cancer

被引：210
作者：
Jenq, Robert R.
van den Brink, Marcel R. M. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Dept Immunol, New York, NY 10065 USA
来源：
NATURE REVIEWS CANCER | 2010年 / 10卷 / 03期
关键词：
GRAFT-VERSUS-HOST; UMBILICAL-CORD BLOOD; BONE-MARROW-TRANSPLANTATION; NATURAL-KILLER-CELLS; SEVERE COMBINED IMMUNODEFICIENCY; T-CELLS; PERIPHERAL-BLOOD; UNRELATED DONOR; ADOPTIVE IMMUNOTHERAPY; HEMATOLOGIC MALIGNANCIES;
D O I：
10.1038/nrc2804
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The year 2009 marked the fiftieth anniversary of the first successful allogeneic haematopoietic stem cell transplant (HSCT). The field of HSCT has pioneered some of the most exciting areas of research today. HSCT was the original stem cell therapy, the first cancer immune therapy and the earliest example of individualized cancer therapy. In this Timeline article we review the history of the development of HSCT and major advances made in the past 50 years. We highlight accomplishments made by researchers who continue to strive to improve outcomes for patients and increase the availability of this potentially life-saving therapy for patients with otherwise incurable malignancies.
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页码：213 / 221
页数：9
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