Electrochemical oxidative annulation of amines and aldehydes or ketones to synthesize polysubstituted pyrroles

被引：39

作者：

Gao, Xinlong ^{[1
]}

Wang, Pan ^{[1
]}

Wang, Qingqing ^{[1
]}

Chen, Jingting ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan 430072, Hubei, Peoples R China

[2] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China

来源：

GREEN CHEMISTRY | 2019年 / 21卷 / 18期

基金：

中国国家自然科学基金;

关键词：

H BOND FUNCTIONALIZATION; PAAL-KNORR SYNTHESIS; MEDIATED SYNTHESIS; CONCISE SYNTHESES; ELECTROSYNTHESIS; LAMELLARINS; DERIVATIVES; ALKALOIDS; ALKENES;

D O I：

10.1039/c9gc02118c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and practical protocol to synthesize polysubstituted pyrroles has been established by electrooxidative annulation of amines and aldehydes or ketones. In an undivided cell, arylacetaldehydes and primary amines can participate in this transformation smoothly to furnish beta-substituted pyrroles under external oxidant-free conditions. Tetrasubstituted pyrroles could be obtained efficiently by using imines as substrates. In addition, this reaction can be extended to gram levels; the final products can also undergo late stage functionalization.

引用

页码：4941 / 4945

页数：5

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