YjhS (NanS) Is Required for Escherichia coli To Grow on 9-O-Acetylated N-Acetylneuraminic Acid

被引:38
作者
Steenbergen, Susan M. [1 ]
Jirik, Jamie L. [1 ]
Vimr, Eric R. [1 ]
机构
[1] Univ Illinois, Lab Sialobiol, Dept Pathobiol, Urbana, IL 61802 USA
关键词
O-ACETYL ESTERASE; SIALIC-ACID; CARBON NUTRITION; INTESTINAL-TRACT; MOUSE INTESTINE; METABOLISM; CATABOLISM; K1; GLYCOSULFATASE; IDENTIFICATION;
D O I
10.1128/JB.01000-09
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid esterase required for E. coli to grow on this alternative sialic acid, which is commonly found in mammalian host mucosal sites.
引用
收藏
页码:7134 / 7139
页数:6
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