Treatment of aggressive adult T-cell leukemia/lymphoma: a retrospective study in a hospital located in HTLV-1 highly endemic area

被引：3
作者：
Nakamura, Daisuke [1 ,2 ]
Yoshimitsu, Makoto [2 ]
Tabuchi, Tomohisa [1 ,2 ]
Arima, Naosuke [1 ,2 ]
Hayashida, Maiko [1 ,2 ]
Inoue, Hirosaka [1 ,2 ]
Matsushita, Kakushi [1 ,2 ]
Matsumoto, Tadashi [1 ]
Arima, Naomichi [2 ]
Ishitsuka, Kenji [2 ]
机构：
[1] Izuro Imamura Hosp, Dept Hematol, 17-1 Horie, Kagoshima, Japan
[2] Kagoshima Univ Hosp, Dept Hematol & Rheumatol, 8-35-1 Sakuragaoka, Kagoshima, Japan
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2020年 / 111卷 / 02期
关键词：
ATL; HTLV-1; OPEC; MPEC; VCAP-AMP-VECP; RDI; LEUKEMIA-LYMPHOMA; COMBINATION CHEMOTHERAPY; JAPAN; SURVIVAL; FEATURES;
D O I：
10.1007/s12185-019-02769-w
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell neoplasm associated with the human T-cell leukemia virus type-I (HTLV-1); prognosis still remains very poor. We retrospectively reviewed the treatment of 198 patients with acute-, lymphoma- and unfavorable chronic-type ATL (aggressive ATL) diagnosed from 2005 to 2014 in a hospital located in an area of Japan in which HTLV-1 is highly endemic. One-hundred forty-three, and 35 patients were treated using OPEC/MPEC and VCAP-AMP-VECP, respectively. OPEC/MPEC was mainly used until around 2010, and gradually switched to VCAP-AMP-VECP, especially for younger patients. The 2-year overall survival for patients treated by VCAP-AMP-VECP was significantly higher than that using OPEC/MPEC for patients < 70 years old (y.o.), but not for patients >= 70 y.o. A less intensive chemotherapy OPEC/MPEC could be performed without reducing dose intensity, even in elderly patients, and its therapeutic outcome is not inferior to that of VCAP-AMP-VECP. It is difficult to draw definite conclusion from this small retrospective study; however, OPEC/MPEC may represent an alternative option for elderly patients with aggressive ATL.
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页码：234 / 240
页数：7
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