GnRHR gene polymorphisms and their effects on reproductive performance in Chinese goats

被引：30

作者：

An, X. P. ^{[1
]}

Han, D. ^{[1
]}

Hou, J. X. ^{[1
]}

Li, G. ^{[1
]}

Wang, J. G. ^{[1
]}

Yang, M. M. ^{[1
]}

Song, Y. X. ^{[1
]}

Zhou, G. Q. ^{[1
]}

Wang, Y. N. ^{[1
]}

Ling, L. ^{[1
]}

Yan, Q. M. ^{[1
]}

Cao, B. Y. ^{[1
]}

机构：

[1] NW A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

来源：

SMALL RUMINANT RESEARCH | 2009年 / 85卷 / 2-3期

关键词：

GnRHR; Polymorphisms; Litter size; Goat; GONADOTROPIN-RELEASING-HORMONE; RECEPTOR GENE; GRANULOSA-CELLS; ASSOCIATION; EXPRESSION; MUTATION; TRAITS; OVARY; IB;

D O I：

10.1016/j.smallrumres.2009.09.001

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

In this study, polymorphisms in the goat GnRHR gene exon 1 were detected by PCR-SSCP and DNA sequencing methods in 786 individuals from two different goat breeds. Two haplotypes (A and B), two observed genotypes (AA and AB), and two single nucleotide polymorphisms (SNPs) were detected, which resulted in five amino acid substitutions. The frequencies of haplotypes A and B in the two goat breeds were 0.78-0.83 and 0.17-0.22, respectively. The SNP locus was in Hardy-Weinberg disequilibrium in the two goat breeds (P < 0.05). Polymorphisms of the GnRHR gene were shown to be associated with litter size in the two goat breeds. The SNPs in the goat GnRHR gene had significant effects on litter size (P < 0.05). Therefore, these results suggest that the GnRHR gene is a strong candidate gene that affects litter size in goat. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：130 / 134

页数：5

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