Effect of zaldaride maleate, an antidiarrheal compound, on 16,16-dimethyl prostaglandin E2-induced intestinal ion secretion in rats

被引：1
作者：
Aikawa, N [1 ]
Karasawa, A [1 ]
Ohmori, K [1 ]
机构：
[1] Kyowa Hakko Kogyo Co Ltd, Pharmaceut Res Inst, Drug Dev Res Labs, Nagaizumi, Shizuoka 4118731, Japan
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 2000年 / 83卷 / 03期
关键词：
zaldaride maleate; calmodulin; intestinal secretion;
D O I：
10.1254/jjp.83.269
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of zaldaride, a calmodulin inhibitor, on 16,16-dimethyl prostaglandin E-2 (dmPGE(2))induced intestinal ion secretion was investigated in rats. Zaldaride inhibited the dmPGE(2)-induced increase in water content in the colon, but not that in the small intestine. In the colonic mucosa, zaldaride attenuated the dmPGE(2)-induced short-circuit current; however, it did not affect the forskolin or dibutyryl cAMP-induced effect. These results suggest that zaldaride inhibits dmPGE(2)-induced intestinal ion secretion by reducing the activity of Ca2+/calmodulin-dependent adenylate cyclase linked to a receptor, and the colon may be an important site in the action of zaldaride.
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收藏
页码：269 / 272
页数：4
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