Serine protease mechanism and specificity

被引：1405
|
作者：
Hedstrom, L [1 ]
机构：
[1] Brandeis Univ, Dept Biochem, Waltham, MA 02454 USA
来源：
CHEMICAL REVIEWS | 2002年 / 102卷 / 12期
关键词：
D O I：
10.1021/cr000033x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Serine... A review is given on the recent work on the mechanism and specificity of chymotrypsin-like enzymes, with the occassional references to pertinent experiments with subtilisin. Focus is on the expression of specificity during catalysis and strategies for substrate discrimination, emphasizing the chymotrypsin-trypsin-elastase paradigm and including examples from Factor D, alpha lytic protease, and thrombin.
引用
收藏
页码：4501 / 4523
页数：23
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