Roles of microRNAs in Gastrointestinal Cancer Stem Cell Resistance and Therapeutic Development

被引：15

作者：

Hwang, Ga-Ram ^{[1
]}

Yuen, John G. ^{[1
]}

Ju, Jingfang ^{[1
]}

机构：

[1] SUNY Stony Brook, Renaissance Sch Med, Dept Pathol, Stony Brook, NY 11794 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 04期

关键词：

cancer stem cells; microRNAs; cancer therapeutics; colorectal cancer; gastric cancer; pancreatic cancer; liver cancer; TUMOR-INITIATING CELLS; HEPATOCELLULAR-CARCINOMA CELLS; PANCREATIC STELLATE CELLS; COLORECTAL-CANCER; MESENCHYMAL TRANSITION; IDENTIFICATION; CHEMORESISTANCE; INHIBITION; EXPRESSION; COLON;

D O I：

10.3390/ijms22041624

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Resistance to cancer treatment is one of the major challenges currently faced when treating gastrointestinal (GI) cancers. A major contributing factor to this resistance is the presence of cancer stem cells (CSCs) in GI cancers (e.g., colorectal, pancreatic, gastric, liver cancer). Non-coding RNAs, such as microRNAs (miRNAs), have been found to regulate several key targets that are responsible for cancer stemness, and function as oncogenic miRNAs (oncomiRs) or tumor suppressor miRNAs. As a result, several miRNAs have been found to alter, or be altered by, the expression of CSC-defining markers and their related pathways. These miRNAs can be utilized to affect stemness in multiple ways, including directly targeting CSCs and enhancing the efficacy of cancer therapeutics. This review highlights current studies regarding the roles of miRNAs in GI CSCs, and efforts towards the development of cancer therapeutics.

引用

页码：1 / 18

页数：18

共 129 条

[1] Mechanisms of chemoresistance in cancer stem cells [J].

Abdullah, Lissa Nurrul ;

Chow, Edward Kai-Hua .

CLINICAL AND TRANSLATIONAL MEDICINE, 2013, 2

[2] Transforming Growth Factor-β in the Gastrointestinal and Hepatic Tumor Microenvironment [J].

Achyut, Bhagelu Ram ;

Yang, Li .

GASTROENTEROLOGY, 2011, 141 (04) :1167-1178

[3] The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance [J].

Ahmed, Sunjida ;

Bradshaw, Azore-Dee ;

Gera, Shweta ;

Dewan, M. Zahidunnabi ;

Xu, Ruliang .

JOURNAL OF CLINICAL MEDICINE, 2017, 6 (01)

[4] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[5] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].

Baden, Lindsey R. ;

El Sahly, Hana M. ;

Essink, Brandon ;

Kotloff, Karen ;

Frey, Sharon ;

Novak, Rick ;

Diemert, David ;

Spector, Stephen A. ;

Rouphael, Nadine ;

Creech, C. Buddy ;

McGettigan, John ;

Khetan, Shishir ;

Segall, Nathan ;

Solis, Joel ;

Brosz, Adam ;

Fierro, Carlos ;

Schwartz, Howard ;

Neuzil, Kathleen ;

Corey, Larry ;

Gilbert, Peter ;

Janes, Holly ;

Follmann, Dean ;

Marovich, Mary ;

Mascola, John ;

Polakowski, Laura ;

Ledgerwood, Julie ;

Graham, Barney S. ;

Bennett, Hamilton ;

Pajon, Rolando ;

Knightly, Conor ;

Leav, Brett ;

Deng, Weiping ;

Zhou, Honghong ;

Han, Shu ;

Ivarsson, Melanie ;

Miller, Jacqueline ;

Zaks, Tal .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416

[6] DCLK1 Marks a Morphologically Distinct Subpopulation of Cells With Stem Cell Properties in Preinvasive Pancreatic Cancer [J].

Bailey, Jennifer M. ;

Alsina, Janivette ;

Rasheed, Zeshaan A. ;

McAllister, Florencia M. ;

Fu, Ya-Yuan ;

Plentz, Ruben ;

Zhang, Hao ;

Pasricha, Pankaj J. ;

Bardeesy, Nabeel ;

Matsui, William ;

Maitra, Anirban ;

Leach, Steven D. .

GASTROENTEROLOGY, 2014, 146 (01) :245-256

[7] Glioma stem cells promote radioresistance by preferential activation of the DNA damage response [J].

Bao, Shideng ;

Wu, Qiulian ;

McLendon, Roger E. ;

Hao, Yueling ;

Shi, Qing ;

Hjelmeland, Anita B. ;

Dewhirst, Mark W. ;

Bigner, Darell D. ;

Rich, Jeremy N. .

NATURE, 2006, 444 (7120) :756-760

[8] Cancer Stem Cells and Targeting Strategies [J].

Barbato, Luisa ;

Bocchetti, Marco ;

Di Biase, Anna ;

Regad, Tarik .

CELLS, 2019, 8 (08)

[9] Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].

Barker, Nick ;

van Es, Johan H. ;

Kuipers, Jeroen ;

Kujala, Pekka ;

van den Born, Maaike ;

Cozijnsen, Miranda ;

Haegebarth, Andrea ;

Korving, Jeroen ;

Begthel, Harry ;

Peters, Peter J. ;

Clevers, Hans .

NATURE, 2007, 449 (7165) :1003-U1

[10] Cancer stem cells revisited [J].

Batlle, Eduard ;

Clevers, Hans .

NATURE MEDICINE, 2017, 23 (10) :1124-1134

← 1 2 3 4 5 6 7 8 9 10 →