Effects of acupuncture on the 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of exercised rats

被引：17
作者：
Lee, SH
Chung, SH
Lee, JS
Kim, SS
Shin, HD
Lim, BV
Jang, MH
Kim, H
Kim, EH
Kim, CJ
机构：
[1] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul 130701, South Korea
[2] Korea Univ, Res Inst Sports Sci, Seoul 136701, South Korea
[3] Semyung Univ, Coll Oriental Med, Dept Meridianol, Jechon, South Korea
[4] Kyung Hee Univ, Coll Oriental Med, Dept Oriental Rehabil Med, Seoul 130701, South Korea
来源：
NEUROSCIENCE LETTERS | 2002年 / 332卷 / 01期
关键词：
acupuncture; Zusanli acupoint; treadmill exercise; 5-hydroxytryptamine; tryptophan hydroxylase; dorsal raphe;
D O I：
10.1016/S0304-3940(02)00900-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In the present study, the effects of acupuncture on the endurance treadmill exercise, serotonin (5-hydroxytryptamine, 5-HT) synthesis, and tryptophan hydroxylase (TPH) expression in the dorsal raphe nuclei were investigated. Acupunctural stimulation were bilaterally inserted into the locus of Zusanli in each hind leg for 20 min. Onset of exhaustion time on the treadmill running was increased significantly by acupunctural stimulation and exercise-induced increments of the 5-HT synthesis and TPH expression in the dorsal raphe were suppressed by acupunctural stimulation. Based on the results, it can be suggested that the suppressive effects of acupunctural stimulation on the 5-HT synthesis and TPH expression in the dorsal raphe during exercise is one of ergogenic mechanisms of acupuncture. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
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页码：17 / 20
页数：4
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