Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart

被引：33

作者：

Ikeda, Shohei ^{[1
,2
]}

Mukai, Risa ^{[1
]}

Mizushima, Wataru ^{[1
]}

Zhai, Peiyong ^{[1
]}

Oka, Shin-ichi ^{[1
]}

Nakamura, Michinari ^{[1
]}

Del Re, Dominic P. ^{[1
]}

Sciarretta, Sebastiano ^{[3
,4
]}

Hsu, Chiao-Po ^{[5
]}

Shimokawa, Hiroaki ^{[2
]}

Sadoshima, Junichi ^{[1
]}

机构：

[1] Rutgers New Jersey Med Sch, Cardiovasc Res Inst, Dept Cell Biol & Mol Med, 185 South Orange Ave,MSB G609, Newark, NJ 07103 USA

[2] Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Sendai, Miyagi, Japan

[3] Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Latina, Italy

[4] Ist Ricovero & Cura Carattere Sci Neuromed, Pozzilli, Italy

[5] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Sch Med, Div Cardiovasc Surg,Dept Surg, Taipei, Taiwan

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2019年 / 4卷 / 05期

关键词：

diabetes; diabetic cardiomyopathy; Hippo pathway; pressure overload; METABOLIC SYNDROME; HIPPO PATHWAY; CARDIOMYOPATHY; ACTIVATION; APOPTOSIS; SURVIVAL; FAILURE;

D O I：

10.1016/j.jacbts.2019.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with diabetes are more prone to developing heart failure in the presence of high blood pressure than those without diabetes. Yes-associated protein (YAP), a key effector of the Hippo signaling pathway, is persistently activated in diabetic hearts, and YAP plays an essential role in mediating the exacerbation of heart failure in response to pressure overload in the hearts of mice fed a high-fat diet. YAP induced dedifferentiation of cardiomyocytes through activation of transcriptional enhancer factor 1 (TEAD1), a transcription factor. Thus, YAP and TEAD1 are promising therapeutic targets for diabetic patients with high blood pressure to prevent the development of heart failure. (C) 2019 Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：611 / 622

页数：12

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