Reduced thalamic resting-state functional connectivity and impaired cognition in acute abstinent heroin users

被引:20
作者
Zhang, Min [1 ,2 ]
Liu, Shuang [1 ,2 ]
Wang, Shicong [1 ,2 ]
Xu, Yan [1 ,2 ]
Chen, Longmao [1 ,2 ]
Shao, Ziqiang [1 ,2 ]
Wen, Xinwen [1 ,2 ]
Yang, Wenhan [3 ]
Liu, Jun [3 ]
Yuan, Kai [1 ,2 ]
机构
[1] Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
[2] Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian, Peoples R China
[3] Cent South Univ, Xiangya Hosp 2, Dept Radiol, Changsha 410011, Peoples R China
基金
中国国家自然科学基金;
关键词
craving; heroin use; impaired cognition; resting-state functional connectivity; thalamus; FRONTOSTRIATAL CIRCUITS; PREFRONTAL CORTEX; TERM ABSTINENCE; WITHDRAWAL; SEVERITY; COCAINE; STIMULATION; INHIBITION; RESPONSES; SYMPTOMS;
D O I
10.1002/hbm.25346
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
As a critical component of cortico-striato-thalamo-cortical loop in addiction, our understanding of the thalamus in impaired cognition of heroin users (HU) has been limited. Due to the complex thalamic connection with cortical and subcortical regions, thalamus was divided into prefrontal (PFC), occipital (OC), premotor, primary motor, sensory, temporal, and posterior parietal association subregions according to white matter tractography. We adopted seven subregions of bilateral thalamus as regions of interest to systematically study the implications of distinct thalamic nuclei in acute abstinent HU. The volume and resting-state functional connectivity (RSFC) differences of the thalamus were investigated between age-, gender-, and alcohol-matched 37 HU and 33 healthy controls (HCs). Trail making test-A (TMT-A) was adopted to assess cognitive function deficits, which were then correlated with neuroimaging findings. Although no significant different volumes were found, HU group showed decreased RSFC between left PFC_thalamus and middle temporal gyrus as well as between left OC_thalamus and inferior frontal gyrus and supplementary motor area relative to HCs. Meanwhile, the higher TMT-A scores in HU were negatively correlated with PFC_thalamic RSFC with inferior temporal gyrus, fusiform, and precuneus. Craving scores were negatively correlated with OC_thalamic RSFC with accumbens, hippocampus, and insula. Opiate Withdrawal Scale scores were negatively correlated with left PFC/OC_thalamic RSFC with orbitofrontal cortex and medial PFC. We indicated two thalamus subregions separately involvement in cognitive control and craving to reveal the implications of thalamic subnucleus in pathology of acute abstinent HU.
引用
收藏
页码:2077 / 2088
页数:12
相关论文
共 75 条
[1]   Cortical and subcortical contributions to stop signal response inhibition: Role of the subthalamic nucleus [J].
Aron, AR ;
Poldrack, RA .
JOURNAL OF NEUROSCIENCE, 2006, 26 (09) :2424-2433
[2]   Inhibition and impulsivity: Behavioral and neural basis of response control [J].
Bari, Andrea ;
Robbins, Trevor W. .
PROGRESS IN NEUROBIOLOGY, 2013, 108 :44-79
[3]   Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging [J].
Behrens, TEJ ;
Johansen-Berg, H ;
Woolrich, MW ;
Smith, SM ;
Wheeler-Kingshott, CAM ;
Boulby, PA ;
Barker, GJ ;
Sillery, EL ;
Sheehan, K ;
Ciccarelli, O ;
Thompson, AJ ;
Brady, JM ;
Matthews, PM .
NATURE NEUROSCIENCE, 2003, 6 (07) :750-757
[4]   Administration and interpretation of the trail making test [J].
Bowie, Christopher R. ;
Harvey, Philip D. .
NATURE PROTOCOLS, 2006, 1 (05) :2277-2281
[5]  
BRADLEY BP, 1987, BRIT J ADDICT, V82, P1139
[6]   Striatum morphometry is associated with cognitive control deficits and symptom severity in internet gaming disorder [J].
Cai, Chenxi ;
Yuan, Kai ;
Yin, Junsen ;
Feng, Dan ;
Bi, Yanzhi ;
Li, Yangding ;
Yu, Dahua ;
Jin, Chenwang ;
Qin, Wei ;
Tian, Jie .
BRAIN IMAGING AND BEHAVIOR, 2016, 10 (01) :12-20
[7]   The precuneus: a review of its functional anatomy and behavioural correlates [J].
Cavanna, AE ;
Trimble, MR .
BRAIN, 2006, 129 :564-583
[8]   Assessing the Role of Corticothalamic and Thalamo-Accumbens Projections in the Augmentation of Heroin Seeking in Chronically Food-Restricted Rats [J].
Chisholm, Alexandra ;
Rizzo, Damaris ;
Fortin, Emilie ;
Moman, Vanessa ;
Quteishat, Nour ;
Romano, Assunta ;
Capolicchio, Tanya ;
Shalev, Uri .
JOURNAL OF NEUROSCIENCE, 2021, 41 (02) :354-365
[9]  
Cortes N., 2020, PULVINAR MODULATES S, P22, DOI [DOI 10.1016/j.cub.2014.03.024, 10.3390/vision4020022, DOI 10.3390/VISION4020022]
[10]   Thalamic Control of Human Attention Driven by Memory and Learning [J].
de Bourbon-Teles, Jose ;
Bentley, Paul ;
Koshino, Saori ;
Shah, Kushal ;
Dutta, Agneish ;
Malhotra, Paresh ;
Egner, Tobias ;
Husain, Masud ;
Soto, David .
CURRENT BIOLOGY, 2014, 24 (09) :993-999