TRISOMY OF CHROMOSOME 8 IN PH-NEGATIVE CELLS OF THE BONE MARROW IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA TREATED WITH INHIBITORS OF BCR-ABL TYROSINKINASES

被引：0

作者：

Turkina, A. G. ^{[1
]}

Domracheva, E. V. ^{[1
]}

Vorontsova, A. V. ^{[1
]}

Aseeva, E. A. ^{[1
]}

Vinogradova, O. Yu. ^{[1
]}

Stakhina, O. V. ^{[1
]}

Gusarova, G. A. ^{[1
]}

Dyagileva, O. A. ^{[1
]}

Semenova, E. A. ^{[1
]}

Vakhrusheva, M. Y. ^{[1
]}

Kolosheinova, T. I. ^{[1
]}

Abakumov, E. M. ^{[1
]}

Chelysheva, E. Yu. ^{[1
]}

Goryacheva, S. R. ^{[1
]}

Ivanova, T. V. ^{[1
]}

Zakharova, E. S. ^{[1
]}

Kolosova, L. Yu. ^{[1
]}

Zakharova, A. V. ^{[1
]}

Naumova, I. N. ^{[1
]}

Dyachenko, L. V. ^{[1
]}

Kulikov, S. M. ^{[1
]}

Kovaleva, L. G. ^{[1
]}

Khoroshko, N. D. ^{[1
]}

机构：

[1] Russian Acad Med Sci, State Hematol Res Ctr, Moscow 109801, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2009年 / 81卷 / 07期

关键词：

chronic myeloid leukemia; chromosome; 8; trisomy; Ph-negative cells; inhibitors of BCR-ABL tyrosinkinase; CHRONIC MYELOGENOUS LEUKEMIA; FLUORESCENCE; ABERRATIONS; CML;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To analyse clinical implications of chromosome 8 trisomy in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia (CML) treated with inhibitors of tyrosinkinases (ITK). Material and methods. A total of 386 patients with CML (chronic phase - 288, acceleration phase - 77) received imatinib (400-800 mg/day). Because of resistance and/or intolerance some patients were switched to ITK H (nilotinib, dasatinib, bozutinib). This study included 8 CML patients (7 in a chronic phase, 1 in acceleration phase) treated with BCR-ABL ITK inhibitors of the first (imatinib) and the second line (ITK-II). The standard cytogenetic examination, on demand - investigation of the interphase nuclei with FISH, in some cases morphological, cytochemical and histological examinations of the bone marrow were made. Results. The existence of a Ph-negative clone with trisomy of chromosome 8 had no negative effect on the course of the disease. The patients showed a stable hematological and cytogenetic response and no need in changing treatment policy. In long-term follow-up Ph-negative clone with trisomy of the chromosome 8 persisted without a clear trend to rise in most patients. Conclusion. Detection of a Ph-negative clone with chromosome 8 trisomy at early stages suggests parallel existence of Ph-positive and Ph-negative clones. None of the patients had myelodisplasia.

引用

页码：29 / 36

页数：8

共 21 条

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