Comparison of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer: a meta-analysis

被引：25

作者：

Jing, Shao-wu ^{[1
]}

Qin, Jian-jun ^{[2
,3
]}

Liu, Qing ^{[1
]}

Zhai, Chang ^{[1
]}

Wu, Ya-jing ^{[1
]}

Cheng, Yun-jie ^{[1
]}

Czito, Brian G. ^{[4
]}

Wang, Jun ^{[1
]}

机构：

[1] Hebei Med Univ, Hosp 4, Dept Radiat Oncol, Shijiazhuang 050011, Hebei, Peoples R China

[2] Chinese Acad Med Sci, Natl Clin Res Ctr Canc, Dept Thorac Surg, Natl Canc Ctr,Canc Hosp, Beijing 100021, Peoples R China

[3] Peking Union Med Coll, Beijing 100021, Peoples R China

[4] Duke Univ, Dept Radiat Oncol, Durham, NC 27708 USA

来源：

FUTURE ONCOLOGY | 2019年 / 15卷 / 20期

关键词：

chemoradiotherapy; chemotherapy; complication; esophageal neoplasms; meta-analysis; neoadjuvant; overall survival; pathological complete regression; progression-free survival; R0 resection rate; RESECTABLE ESOPHAGEAL; SURVIVAL; CARCINOMA; CHEMORADIATION; SURGERY; THERAPY; TRIAL;

D O I：

10.2217/fon-2019-0024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To compare the clinical efficacy of neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT) for esophageal cancer. Methods: Randomized controlled trials reporting on the comparison of nCRT and nCT for esophageal cancer were identified. Results: Three eligible randomized controlled trials were identified and included with a total of 375 patients (189 nCRT, 186 nCT). Outcomes showed that compared with nCT group, R0 resection and pathologic complete response (pCR) rates were significantly increased in nCRT group. However, no significant difference was seen in 3- and 5-year progression-free survival or 3- and 5-year overall survival. Conclusion: The addition of radiotherapy to neoadjuvant chemotherapy results in higher R0 resection rate and pCR rate, without significantly impacting survival.

引用

页码：2413 / 2422

页数：10

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