Preliminary Results for the Inhibition of Pancreatic Cancer Cells by Organotin Polymers

被引：25
|
作者：
Roner, Michael R. [2 ]
Shahi, Kimberly R. [2 ]
Barot, Girish [1 ,3 ]
Battin, Amitabh [1 ,3 ]
Carraher, Charles E., Jr. [1 ,3 ]
机构：
[1] Florida Atlantic Univ, Dept Chem & Biochem, Boca Raton, FL 33431 USA
[2] Univ Texas Arlington, Dept Biol, Arlington, TX 76010 USA
[3] Florida Ctr Environm Studies, Palm Beach Gardens, FL 33410 USA
来源：
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS | 2009年 / 19卷 / 03期
关键词：
Pancreatic cancer; Organotin polymers; Pancreatic cancer chemotherapy; Organotin polyethers; Soluble organotin polyethers; Organotin polyamines; STRUCTURAL-CHARACTERIZATION; PRELIMINARY ANTICANCER; TITANOCENE DICHLORIDE; DIETHYLSTILBESTROL; DERIVATIVES; POLYETHERS; DRUGS;
D O I：
10.1007/s10904-009-9275-7
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Pancreatic cancer kills nearly all patients within 3-6 months after detection. There is no effective chemotherapy for it. We have found a number of organotin polymers that are effective at inhibiting pancreatic cancer cell lines with Chemotherapeutic Index values greater than two with some to values of 50.
引用
收藏
页码：410 / 414
页数：5
相关论文
共 50 条
  • [41] Comparative testing of various pancreatic cancer stem cells results in a novel class of pancreatic-cancer-initiating cells
    Jaiswal, Kshama R.
    Xin, Hong-Wu
    Anderson, Andrew
    Wiegand, Gordon
    Kim, Bo
    Miller, Tyler
    Hari, Danielle
    Ray, Satyajit
    Koizumi, Tomotake
    Rudloff, Udo
    Thorgeirsson, Snorri S.
    Avital, Itzhak
    STEM CELL RESEARCH, 2012, 9 (03) : 249 - 260
  • [42] Bacterial and yeast inhibition by organotin polymers and model compounds derived from ciprofloxacin
    Naoshima, Yoshinobu
    Nagao, Kazutaka
    Mori, Yoshihiro
    Carraher, Charles E., Jr.
    Zhao, Anna
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [43] SBRT in Unresectable Advanced Pancreatic Cancer: Preliminary Results of a Single Institutional Experience
    Alongi, F.
    Tozzi, A.
    Comito, T.
    Iftode, C.
    Mancosu, P.
    Cozzi, L.
    Zerbi, A.
    Tomatis, S.
    Navarria, P.
    Scorsetti, M.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 87 (02): : S305 - S305
  • [44] Percutaneous Radiofrequency Ablation of Unresectable Locally Advanced Pancreatic Cancer: Preliminary Results
    D'Onofrio, Mirko
    Crosara, Stefano
    De Robertis, Riccardo
    Butturini, Giovanni
    Salvia, Roberto
    Paiella, Salvatore
    Bassi, Claudio
    Mucelli, Roberto Pozzi
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2017, 16 (03) : 285 - 294
  • [45] The Preliminary Results of High-Intensity Focused Ultrasound in Patients With Pancreatic Cancer
    Bang, Byoung Wook
    Lee, Jung Il
    Jeong, Seok
    Lee, Jin-Woo
    Kwon, Kye Sook
    Lee, Don Haeng
    Kim, Hyung Gil
    Shin, Yong Woon
    Kim, Young Soo
    Kim, Won Hong
    Hwang, Joo Ha
    GASTROENTEROLOGY, 2010, 138 (05) : S452 - S452
  • [46] Cyberknife (CK) radiosurgery in the treatment of non resectable pancreatic cancer: Preliminary results
    Meregalli, M.
    Merlotti, A.
    Bianchi, L. C.
    Brambilla, A.
    Dellafiore, L.
    Locatelli, M. C.
    Tabiadon, D.
    Fariselli, L.
    ANNALS OF ONCOLOGY, 2006, 17 : XI52 - XI52
  • [47] Drug-eluting Microparticles for the Treatment of Pancreatic Cancer: Preliminary in vivo Results
    Asgharpour, A.
    Ganesh, M.
    Gooding, A.
    Stanek, A.
    Andrawes, S.
    Danishpajooh, I.
    Gross, R.
    Gress, F.
    Martello-Rooney, L.
    PANCREAS, 2011, 40 (08) : 1311 - 1311
  • [48] Preliminary Results of Hyperthermic Intraperitoneal Intraoperative Chemotherapy as an Adjuvant in Resectable Pancreatic Cancer
    Tentes, Antonios-Apostolos K.
    Kyziridis, Dimitrios
    Kakolyris, Stylianos
    Pallas, Nicolaos
    Zorbas, Georgios
    Korakianitis, Odysseas
    Mavroudis, Christos
    Courcoutsakis, Nicolaos
    Prasopoulos, Panos
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2012, 2012
  • [49] Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result
    Kurihara, Toshio
    Itoi, Takao
    Sofuni, Atsushi
    Itokawa, Fumihide
    Tsuchiya, Takayoshi
    Tsuji, Shujirou
    Ishii, Kentaro
    Ikeuchi, Nobuhito
    Tsuchida, Akihiko
    Kasuya, Kazuhiko
    Kawai, Takashi
    Sakai, Yoshihiro
    Moriyasu, Fuminori
    JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY, 2008, 15 (02): : 189 - 195
  • [50] Comparison of WI-38 and NIH/3T3 cells as standards for the evaluation of pancreatic cancer cell lines by organotin polymers containing histamine and phentolamine
    Roner, Michael R.
    Carraher, Charles E., Jr.
    Moric, Alisa
    Nancy Trang
    Islam, Zamil
    Ngoc Trang Caroline Truong
    Williams-Sheffler, Jessica
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
12345