Higher Levels of Urinary Albumin Excretion Within the Normal Range Predict Easter Decline in Glomerular Filtration Rate in Diabetic Patients

被引：48

作者：

Babazono, Tetsuya ^{[1
,2
]}

Ohta, Mari ^{[1
,2
]}

Nyumura, Izumi ^{[1
,2
]}

Suzuki, Kumi ^{[1
,2
]}

Toya, Kiwako ^{[1
,2
]}

Kiuchi, Yuka ^{[1
,2
]}

Hayashi, Toshihide ^{[1
,2
]}

Iwamoto, Yasuhiko ^{[1
]}

机构：

[1] Tokyo Womens Univ, Sch Med, Div Nephrol & Hypertens, Tokyo, Japan

[2] Tokyo Womens Univ, Sch Med, Ctr Diabet, Dept Med, Tokyo, Japan

来源：

DIABETES CARE | 2009年 / 32卷 / 08期

关键词：

KIDNEY-FUNCTION; MICROALBUMINURIA; DEFINITION; DISEASE; NEPHROPATHY; PROGRESSION; PREVALENCE; RISK;

D O I：

10.2337/dc08-2151

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To assess the relationship between albuminuria, including elevation within the normal range, and decline in glomerular filtration rate < GFR) in diabetic patients. RESEARCH DESIGN AND METHODS - A total of 5,449 Japanese diabetic patients were categorized according to sex and urinary albumin-to-creatinine ratio (ACR; <5, 5-9, 10-29, 30-99, 100-299, 300-999, 1,000-2,999, and >= 3,000 mg/g) and followed for at least 5 years. The rate of change in estimated GFR (eGFR) adjusted for age and baseline eGFR was compared among ACR categories. RESULTS - A higher baseline ACR predicted a faster decline in eGFR for both sexes. Even within the normal range (<30 mg/g), ACR >= 10 mg/g in women and >= 5 mg/g in men was associated with a significantly greater rate of decline in eGFR relative to subjects with ACR <5 mg/g. CONCLUSIONS - Elevated ACR, even within the normal range, is associated with a faster decline in eGFR in diabetic patients.

引用

页码：1518 / 1520

页数：3

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