Anti-Markovnikov Hydroarylation of Unactivated Olefins via Pyridyl Radical Intermediates

被引：107

作者：

Boyington, Allyson J. ^{[1
]}

Riu, Martin-Louis Y. ^{[1
]}

Jui, Nathan T. ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Winship Canc Inst, 1515 Pierce Dr, Atlanta, GA 30322 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2017年 / 139卷 / 19期

关键词：

C-H FUNCTIONALIZATION; NITROGEN-HETEROCYCLES; BOND ACTIVATION; ALKYLATION; CATALYSIS; PHOTOCATALYSIS; GENERATION; ARYLATION; ALKENES; ACCESS;

D O I：

10.1021/jacs.7b03262

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The intermolecular alkylation of pyridine units with simple alkenes has been achieved via a photoredox radical mechanism. This process occurs with complete regiocontrol, where single-electron reduction of halogenated pyridines regiospecifically yields the corresponding radicals in a programmed fashion, and radical addition to alkene substrates occurs with exclusive antiMarkovnikov selectivity. This system is mild, tolerant of many functional groups, and effective for the preparation of a wide range of complex alkylpyridines.

引用

页码：6582 / 6585

页数：4

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