Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

被引:5
作者
Xu, Changzhi [1 ]
Yang, Ling [1 ]
Yuan, Yuan [2 ]
Du, Fei [2 ]
Wang, Shumin [1 ]
Wang, Xiangfang [1 ]
Zhu, Lin [1 ]
Zhang, Buchang [1 ]
Weaver, David [1 ]
机构
[1] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 3, Binhu Hosp, Cent Lab, Hefei 230601, Anhui, Peoples R China
关键词
Listeria monocytogenes; CYLD; Apoptosis; NF-KAPPA-B; DEUBIQUITINATING ENZYME; GENE; PATHOGENESIS; INFECTIONS; ACTIVATION; EXPRESSION; RESPONSES; BACTERIAL; MICE;
D O I
10.1016/j.micpath.2015.10.007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-kappa B pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:50 / 54
页数:5
相关论文
共 50 条
[31]   Resveratrol induces apoptosis in breast cancer cells by E2F1-mediated up-regulation of ASPP1 [J].
Shi, Yujie ;
Yang, Shihe ;
Troup, Sandi ;
Lu, Xin ;
Callaghan, Steve ;
Park, David S. ;
Xing, Ying ;
Yang, Xiaohe .
ONCOLOGY REPORTS, 2011, 25 (06) :1713-1719
[32]   Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-κB Pathway in Bladder Cancer Cells [J].
Deng, Yuyou ;
Bi, Ran ;
Guo, Haoran ;
Yang, Jiaxin ;
Du, Yujun ;
Wang, Chunxi ;
Wei, Wei .
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2019, 15 (03) :688-700
[33]   The inhibition of apoptosis of hepatoma cells induced by HBx is mediated by up-regulation of survivin expression [J].
Li Donghua ;
Chen Xiaoping ;
Zhang Wanguang .
Current Medical Science, 2003, 23 (4) :383-386
[34]   Piceatannol induced apoptosis through up-regulation of microRNA-181a in melanoma cells [J].
Maotao Du ;
Zhong Zhang ;
Tao Gao .
Biological Research, 50
[35]   The Inhibition of Apoptosis of Hepatoma Cells Induced by HBx Is Mediated by Up-regulation of Survivin Expression [J].
李东华 ;
陈孝平 ;
张万广 .
华中科技大学学报(医学英德文版), 2003, (04) :383-386
[36]   Hypoxia-induced up-regulation of Aquaporin-1 in Rat Schwann cells via the MAPK pathway [J].
Meng, Wei ;
Hu, Hao ;
Jie, Xiang ;
Gao, Yak ;
Zhu, Lie ;
Zhang, Ying ;
Zhao, Yaozh ;
Wang, Hui ;
Jiang, Hua .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (06) :9271-9276
[37]   Synthesis of Copper-Platinum Nanoparticles Induce Apoptosis in THP-1 cells [J].
Alshatwi, Ali A. ;
Athinarayanan, Jegan ;
Periasamy, Vaiyapuri Subbarayan ;
Prato, Maurizio .
2015 IEEE 15TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO), 2015, :1111-1113
[38]   Transcriptional up-regulation of relaxin-3 by Nur77 attenuates -adrenergic agonist-induced apoptosis in cardiomyocytes [J].
You, Xiaohua ;
Guo, Zhi-Fu ;
Cheng, Fang ;
Yi, Bing ;
Yang, Fan ;
Liu, Xinzhu ;
Zhu, Ni ;
Zhao, Xianxian ;
Yan, Guijun ;
Ma, Xin-Liang ;
Sun, Jianxin .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (36) :14001-14011
[39]   Proteomic changes induced by histone demethylase JMJD3 in TNF alpha-treated human monocytic (THP-1) cells [J].
Das, Amitabh ;
Das, Nando Dulal ;
Jung, Kyoung Hwa ;
Park, Ji Hyun ;
Lee, Hyung Tae ;
Han, DalMuri ;
Choi, Mi Ran ;
Kang, Sung Chul ;
Chai, Young Gyu .
MOLECULAR IMMUNOLOGY, 2013, 56 (1-2) :113-122
[40]   Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway [J].
Ahmad, Bashir ;
Gamallat, Yaser ;
Su, Pengyu ;
Husain, Akbar ;
Rehman, Ata Ur ;
Zaky, Mohamed Y. ;
Bakheet, Ahmed Musa Hago ;
Tahir, Naeem ;
Xin, Yi ;
Liang, Wang .
CHEMICAL BIOLOGY & DRUG DESIGN, 2021, 97 (02) :266-272