Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

被引：5

作者：

Xu, Changzhi ^{[1
]}

Yang, Ling ^{[1
]}

Yuan, Yuan ^{[2
]}

Du, Fei ^{[2
]}

Wang, Shumin ^{[1
]}

Wang, Xiangfang ^{[1
]}

Zhu, Lin ^{[1
]}

Zhang, Buchang ^{[1
]}

Weaver, David ^{[1
]}

机构：

[1] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 3, Binhu Hosp, Cent Lab, Hefei 230601, Anhui, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2016年 / 90卷

关键词：

Listeria monocytogenes; CYLD; Apoptosis; NF-KAPPA-B; DEUBIQUITINATING ENZYME; GENE; PATHOGENESIS; INFECTIONS; ACTIVATION; EXPRESSION; RESPONSES; BACTERIAL; MICE;

D O I：

10.1016/j.micpath.2015.10.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-kappa B pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：50 / 54

页数：5

共 50 条

[21] Curcumin confers protection to irradiated THP-1 cells while its nanoformulation sensitizes these cells via apoptosis induction
Soltani, Behrooz
Ghaemi, Nasser
Sadeghizadeh, Majid
Najafi, Farhood
CELL BIOLOGY AND TOXICOLOGY, 2016, 32 (06) : 543 - 561
[22] Vitamin C inhibits apoptosis in THP-1 cells in response to incubation with Mycobacterium tuberculosis
Song, Fuyang
Wu, Yiming
Lin, Xue
Xue, Di
Wang, Yujiong
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2022, 24 (06)
[23] Virosecurinine induces apoptosis in human leukemia THP-1 cells and other underlying molecular mechanisms
Zhang, Gang
Gao, Xiaohui
Zeng, Hui
Li, Yuan
Guo, Xiaojun
ONCOLOGY LETTERS, 2018, 15 (01) : 849 - 854
[24] The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide
Sarmento Rios, Ester Correia
de Lima, Thais Martins
Soares Moretti, Ana Iochabel
Soriano, Francisco Garcia
LIFE SCIENCES, 2016, 147 : 110 - 116
[25] Bcl-2 Regulates the Onset of Shiga Toxin 1-Induced Apoptosis in THP-1 Cells
Lee, Moo-Seung
Cherla, Rama P.
Leyva-Illades, Dinorah
Tesh, Vernon L.
INFECTION AND IMMUNITY, 2009, 77 (12) : 5233 - 5244
[26] Effect of human breast milk on innate immune response: Up-regulation of bacterial pattern recognition receptors and innate cytokines in THP-1 monocytic cells
Hahn, Won-Ho
Shin, Soon Young
Song, Jun Hwan
Kang, Nam Mi
EUROPEAN JOURNAL OF INFLAMMATION, 2021, 19
[27] Effects of pcsk9 siRNA on THP-1 Derived Macrophages Apoptosis Induced by oxLDL
Liu Lu-Shan
Xie Min
Jiang Zhi-Sheng
Yang Qiong
Pan Li-Hong
Wu Chun-Yan
Tang Zhi-Han
Tang Chao-Ke
Wei Dang-Heng
Wang Zuo
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 36 (03) : 323 - 330
[28] Inhibition of TLR8 mediated signaling promotes BCG induced apoptosis in THP-1 cells
Tang, Jun
Zhan, Lingjun
Qin, Chuan
MICROBIAL PATHOGENESIS, 2016, 93 : 78 - 82
[29] Indoxyl sulfate stimulates oxidized LDL uptake through up-regulation of CD36 expression in THP-1 macrophages
Cao, Longxing
Fu, Qiang
Wang, Bing Hui
Jin, Wen
Li, Zhiliang
JOURNAL OF APPLIED BIOMEDICINE, 2014, 12 (04) : 203 - 209
[30] Protective effect of melittin against inflammation and apoptosis on Propionibacterium acnes-induced human THP-1 monocytic cell
Lee, Woo-Ram
Kim, Kyung-Hyun
An, Hyun-Jin
Kim, Jung-Yeon
Han, Sang-Mi
Lee, Kwang-Gil
Park, Kwan-Kyu
EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 740 : 218 - 226

← 1 2 3 4 5 →