Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

被引：5
作者：
Xu, Changzhi [1 ]
Yang, Ling [1 ]
Yuan, Yuan [2 ]
Du, Fei [2 ]
Wang, Shumin [1 ]
Wang, Xiangfang [1 ]
Zhu, Lin [1 ]
Zhang, Buchang [1 ]
Weaver, David [1 ]
机构：
[1] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China
[2] Anhui Med Univ, Affiliated Hosp 3, Binhu Hosp, Cent Lab, Hefei 230601, Anhui, Peoples R China
来源：
MICROBIAL PATHOGENESIS | 2016年 / 90卷
关键词：
Listeria monocytogenes; CYLD; Apoptosis; NF-KAPPA-B; DEUBIQUITINATING ENZYME; GENE; PATHOGENESIS; INFECTIONS; ACTIVATION; EXPRESSION; RESPONSES; BACTERIAL; MICE;
D O I：
10.1016/j.micpath.2015.10.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-kappa B pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：50 / 54
页数：5
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