Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells

被引：5

作者：

Xu, Changzhi ^{[1
]}

Yang, Ling ^{[1
]}

Yuan, Yuan ^{[2
]}

Du, Fei ^{[2
]}

Wang, Shumin ^{[1
]}

Wang, Xiangfang ^{[1
]}

Zhu, Lin ^{[1
]}

Zhang, Buchang ^{[1
]}

Weaver, David ^{[1
]}

机构：

[1] Anhui Univ, Inst Hlth Sci, Hefei 230601, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 3, Binhu Hosp, Cent Lab, Hefei 230601, Anhui, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2016年 / 90卷

关键词：

Listeria monocytogenes; CYLD; Apoptosis; NF-KAPPA-B; DEUBIQUITINATING ENZYME; GENE; PATHOGENESIS; INFECTIONS; ACTIVATION; EXPRESSION; RESPONSES; BACTERIAL; MICE;

D O I：

10.1016/j.micpath.2015.10.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Listeria monocytogenes (Lm), a facultative anaerobic gram-positive bacterium, causes listeriosis. Immune cell apoptosis is considered to be one pathogenic factor for listeriosis. As a deubiquitinase, CYLD is an important regulator both in innate immune response and apoptosis by negatively modulating NF-kappa B pathway. However the role of CYLD in Lm induced apoptosis remains unclear. Here we found that CYLD is significantly up-regulated in macrophages upon its infection. There is a moderate decrease in Lm proliferation and apoptotic cells in siRNA-induced CYLD knockdown THP-1 cells. Thereby CYLD may be involved in cell apoptosis mediated by Lm infection and its proliferation. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：50 / 54

页数：5

共 50 条

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