Role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II

被引：7

作者：

Schnackenberg, C ^{[1
]}

Tucker, B ^{[1
]}

Pigg, K ^{[1
]}

Granger, L ^{[1
]}

机构：

[1] UNIV MISSISSIPPI, MED CTR, DEPT PHYSIOL & BIOPHYS, JACKSON, MS 39216 USA

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1997年 / 10卷 / 02期

关键词：

kidney; hypertension; renal blood flow dog;

D O I：

10.1016/S0895-7061(96)00331-7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The purpose of this study was to determine longterm role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II (AII). In normal dogs, intrarenal AII infusion (1.0 ng/kg/min) decreased renal plasma now (RPF) by 31% and glomerular filtration rate (GFR) by 17% and increased mean arterial pressure (MAP) by 22%. In dogs with chronic intrarenal NO synthesis blockade with N-omega-nitro-L-arginine methyl ester (3 mu g/kg/min), AII decreased RPF by 25% and GFR by 19%, and increased MAP by 7%. These data indicate that chronic inhibition of NO synthesis within the kidney attenuated the long-term renal and arterial pressure responses to All in dogs. (C) 1997 American Journal of Hypertension, Ltd.

引用

页码：226 / 229

页数：4

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