Role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II

The purpose of this study was to determine longterm role of nitric oxide in modulating the chronic renal and arterial pressure responses to angiotensin II (AII). In normal dogs, intrarenal AII infusion (1.0 ng/kg/min) decreased renal plasma now (RPF) by 31% and glomerular filtration rate (GFR) by 17% and increased mean arterial pressure (MAP) by 22%. In dogs with chronic intrarenal NO synthesis blockade with N-omega-nitro-L-arginine methyl ester (3 mu g/kg/min), AII decreased RPF by 25% and GFR by 19%, and increased MAP by 7%. These data indicate that chronic inhibition of NO synthesis within the kidney attenuated the long-term renal and arterial pressure responses to All in dogs. (C) 1997 American Journal of Hypertension, Ltd.