Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes

被引：5
|
作者：
Chi-Xianggeng [1 ]
Hu-Bo [2 ]
Yu, S. Y. [3 ]
Yin-Lianghong [2 ]
Meng-Yu [2 ]
Wang-Boxun [2 ]
Yang-Jinsheng [2 ]
Lin-Jiahui [2 ]
Huang-Dexu [2 ]
Chen-lanlan [4 ]
机构：
[1] Southern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
[2] JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China
[4] GongAn Hosp Tradit Chinese Med, Wuhan, HuBei, Peoples R China
来源：
JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM | 2015年 / 16卷 / 04期
关键词：
Losartan; TRPC6; proteinuria; podocyte; signal pathway; CHANNELS; INHIBITION; FILTRATION; EXPRESSION;
D O I：
10.1177/1470320315573682
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
Objective: In this study, we investigated the molecule mechanisms of podocyte injury and proteinuria and the protective effects of losartan. Methods: This study set up three groups: a control group; an Ang II group (Ang II 10(-6) mol/l, Sigma); and a losartan group (losartan 10(-6) mol/l, Sigma). We used RT-PCR assay to detect TRPC6 mRNA expression, and Western blot to detect TRPC6 protein expression. Results: TRPC6 overexpression was the basic change of podocyte injury and proteinuria occurrence. Losartan can treat podocyte injury and proteinuria induced by Ang II via downregulation of TRPC6 in podocytes. Conclusion: These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases.
引用
收藏
页码：1118 / 1124
页数：7
相关论文
共 50 条
  • [31] Effect of Down-regulation of TRPC6 on the Puromycin Aminonucleoside-induced Apoptosis of Mouse Podocytes
    孙希锋
    方展
    朱忠华
    杨晓
    何方方
    张春
    JournalofHuazhongUniversityofScienceandTechnology(MedicalSciences), 2009, 29 (04) : 417 - 422
  • [32] FK506 ameliorates podocyte injury in type 2 diabetic nephropathy by down-regulating TRPC6 and NFAT expression
    Ma, Ruixia
    Liu, Liqiu
    Jiang, Wei
    Yu, Yanjuan
    Song, Haifeng
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (11): : 14063 - 14074
  • [33] Downregulation of TRPC6 regulates ERK1/2 to prevent sublytic C5b-9 complement complex-induced podocyte injury through activating autophagy
    Li, Yuanyuan
    Fang, Youfu
    Liu, Jing
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023, 26 (06)
  • [34] Losartan reverses glomerular podocytes injury induced by AngII via stabilizing the expression of GLUT1
    S. Y. Yu
    R. Qi
    H. Zhao
    Molecular Biology Reports, 2013, 40 : 6295 - 6301
  • [35] Activation of urotensin II receptor induces podocyte injury via TRPC6-mediated endoplasmic reticulum stress
    Kanthakumar, Praghalathan
    Adebiyi, Adebowale
    PHYSIOLOGY, 2023, 38
  • [36] Angiotensin II Type I Receptor Agonistic Autoantibody Induces Podocyte Injury via Activation of the TRPC6-Calcium / Calcineurin Pathway in Pre-Eclampsia
    Yu, Ying
    Zhang, Lihong
    Xu, Guang
    Wu, Zhenghong
    Li, Qian
    Gu, Yong
    Niu, Jianying
    KIDNEY & BLOOD PRESSURE RESEARCH, 2018, 43 (05) : 1666 - 1676
  • [37] Atractylodin inhibits fructose-induced human podocyte hypermotility via anti-oxidant to down-regulate TRPC6/p-CaMK4 signaling
    Chen, Li
    Tang, Ya -Li
    Liu, Zhi-Hong
    Pan, Ying
    Jiao, Rui-Qing
    Kong, Ling-Dong
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 913
  • [38] TRPC6 knockdown-mediated ERK1/2 inactivation alleviates podocyte injury in minimal change disease via upregulating Lon peptidase 1
    Ma, Jianwei
    Ren, Liling
    Su, Qin
    Lv, Xiuyi
    Sun, Min
    Wei, Yunbo
    Dai, Lili
    Bian, Xueyan
    RENAL FAILURE, 2024, 46 (02)
  • [39] The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction
    Chen, Xingjuan
    Taylor-Nguyen, Natalie N.
    Riley, Ashley M.
    Herring, B. Paul
    White, Fletcher A.
    Obukhov, Alexander G.
    JOURNAL OF NEUROINFLAMMATION, 2019, 16 (1)
  • [40] The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury
    Wang, Jing
    Zhao, Ming
    Jia, Peng
    Liu, Fang-Fang
    Chen, Kun
    Meng, Fei-Yang
    Hong, Jiang-Hao
    Zhang, Ting
    Jin, Xiao-Hang
    Shi, Juan
    JOURNAL OF NEUROINFLAMMATION, 2020, 17 (01)
12345