Losartan treating podocyte injury induced by Ang II via downregulation of TRPC6 in podocytes
被引:5
|
作者:
Chi-Xianggeng
论文数: 0引用数: 0
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机构:
Southern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Chi-Xianggeng
[1
]
Hu-Bo
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Hu-Bo
[2
]
Yu, S. Y.
论文数: 0引用数: 0
h-index: 0
机构:
Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Yu, S. Y.
[3
]
Yin-Lianghong
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Yin-Lianghong
[2
]
Meng-Yu
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Meng-Yu
[2
]
Wang-Boxun
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Wang-Boxun
[2
]
Yang-Jinsheng
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Yang-Jinsheng
[2
]
Lin-Jiahui
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Lin-Jiahui
[2
]
Huang-Dexu
论文数: 0引用数: 0
h-index: 0
机构:
JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Huang-Dexu
[2
]
Chen-lanlan
论文数: 0引用数: 0
h-index: 0
机构:
GongAn Hosp Tradit Chinese Med, Wuhan, HuBei, Peoples R ChinaSouthern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
Chen-lanlan
[4
]
机构:
[1] Southern Med Univ, Affiliated Xiaolan Hosp, Dept Nephrol, Zhong Shan, Peoples R China
[2] JiNan Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Guangzhou, Guangdong, Peoples R China
[4] GongAn Hosp Tradit Chinese Med, Wuhan, HuBei, Peoples R China
Losartan;
TRPC6;
proteinuria;
podocyte;
signal pathway;
CHANNELS;
INHIBITION;
FILTRATION;
EXPRESSION;
D O I:
10.1177/1470320315573682
中图分类号:
R6 [外科学];
学科分类号:
1002 ;
100210 ;
摘要:
Objective: In this study, we investigated the molecule mechanisms of podocyte injury and proteinuria and the protective effects of losartan. Methods: This study set up three groups: a control group; an Ang II group (Ang II 10(-6) mol/l, Sigma); and a losartan group (losartan 10(-6) mol/l, Sigma). We used RT-PCR assay to detect TRPC6 mRNA expression, and Western blot to detect TRPC6 protein expression. Results: TRPC6 overexpression was the basic change of podocyte injury and proteinuria occurrence. Losartan can treat podocyte injury and proteinuria induced by Ang II via downregulation of TRPC6 in podocytes. Conclusion: These findings maybe provide an ideal drug target for the diagnosis and treatment of acquired glomerular diseases.
机构:
Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Ma, Ruixia
Wang, Ying
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Wang, Ying
Xu, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Xu, Yan
Wang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Intens Care Unit, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Wang, Rui
Wang, Xianghua
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Wang, Xianghua
Yu, Ning
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Ultrasound, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Yu, Ning
Li, Minghui
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Emergency, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
Li, Minghui
Zhou, Yan
论文数: 0引用数: 0
h-index: 0
机构:
Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R ChinaQingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Shandong, Peoples R China
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Harbin Med Univ, Affiliated Hosp 4, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Zhao, Bo
Yang, He
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Yang, He
Zhang, Rui
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Zhang, Rui
Sun, Hui
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Emergency, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Sun, Hui
Liao, Chang
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Liao, Chang
Xu, Jia
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 4, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Xu, Jia
Meng, Kexin
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Meng, Kexin
Jiao, Jundong
论文数: 0引用数: 0
h-index: 0
机构:
Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
Harbin Med Univ, Inst Nephrol, Harbin, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin, Peoples R China
机构:
Duke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Hall, Gentzon
Rowell, Janelle
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Rowell, Janelle
Farinelli, Federica
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Farinelli, Federica
Gbadegesin, Rasheed A.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USA
Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Gbadegesin, Rasheed A.
Lavin, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Trinity Coll Dublin, Tallaght Hosp, Trinity Hlth Kidney Ctr, Dublin, IrelandDuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Lavin, Peter
Wu, Guanghong
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Wu, Guanghong
Homstad, Alison
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Homstad, Alison
Malone, Andrew
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Malone, Andrew
Lindsey, Thomas
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Lindsey, Thomas
Jiang, Ruiji
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Jiang, Ruiji
Spurney, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Spurney, Robert
Tomaselli, Gordon F.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Tomaselli, Gordon F.
Kass, David A.
论文数: 0引用数: 0
h-index: 0
机构:
Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Kass, David A.
Winn, Michelle P.
论文数: 0引用数: 0
h-index: 0
机构:
Duke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
Duke Univ, Med Ctr, Ctr Human Genet, Durham, NC 27710 USADuke Univ, Med Ctr, Div Nephrol, Durham, NC 27710 USA
机构:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USAMed Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA
Ilatovskaya, Daria V.
Staruschenko, Alexander
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA
Med Coll Wisconsin, Cardiovasc Ctr, Milwaukee, WI 53226 USAMed Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA