Elevation of serum high-mobility group box 1 protein during granulocyte colony-stimulating factor-induced peripheral blood stem cell mobilisation

被引：14
作者：
Tagami, Kozo
Yujiri, Toshiaki
Tanimura, Atsuko
Mitani, Noriyuki
Nakamura, Yukinori
Ariyoshi, Koichi
Ando, Toshihiko
Fujii, Yasuhiko
Tanizawa, Yukio
机构：
[1] Yamaguchi Univ, Sch Med, Dept Internal Med 3, Ube, Yamaguchi 7558505, Japan
[2] Yamaguchi Univ, Sch Med, Div Blood Transfus, Ube, Yamaguchi 7558505, Japan
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 135卷 / 04期
关键词：
high mobility group box 1; granulocyte colony-stimulating factor; stem cells; mobilisation;
D O I：
10.1111/j.1365-2141.2006.06335.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High mobility group box 1 (HMGB1) is a non-histone protein involved in maintaining the architecture of chromatin. HMGB1 also acts extracellularly as a cytokine, in processes such as inflammation, cell migration and stem cell recruitment. The involvement of HMGB1 in granulocyte colony-stimulating factor (G-CSF)-induced mobilisation of haematopoietic stem cells was investigated in 21 healthy donors. G-CSF treatment significantly elevated serum HMGB1 levels, which increased from 1.16 +/- 0.86 ng/ml, before treatment, to 31.1 +/- 5.99 ng/ml, after treatment. These findings suggest HMGB1 may play a role during the mobilisation of stem cells from the bone marrow into the systemic circulation.
引用
收藏
页码：567 / 569
页数：3
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