Diabetic dyslipidemia

被引:181
作者
Chahil, Tina J. [1 ]
Ginsberg, Henry N. [1 ]
机构
[1] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA
关键词
D O I
10.1016/j.ecl.2006.06.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Type 2 diabetes mellitus is associated with a markedly increased risk of cardiovascular disease. A complex dyslipidemia, which is an integral part of the underlying insulin resistance in this group, is a key to this increased risk. Increased secretion of VLDL from the liver is a central feature of dyslipidemia and is linked significantly to the low HDL and abnormal LDL that are also present. A number of physiologic and pharmacologic approaches are available and should be used aggressively to treat diabetic dyslipidemia.
引用
收藏
页码:491 / +
页数:22
相关论文
共 76 条
[1]   Foxo1 mediates insulin action on apoC-III and triglyceride metabolism [J].
Altomonte, J ;
Cong, L ;
Harbaran, S ;
Richter, A ;
Xu, J ;
Meseck, M ;
Dong, HJH .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (10) :1493-1503
[2]  
[Anonymous], 2005, National diabetes fact sheet
[3]   LDL DENSITY AND ATHEROSCLEROSIS [J].
AUSTIN, MA ;
KRAUSS, RM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 273 (02) :115-115
[4]   Cardiovascular events in type 2 diabetes: comparison with nondiabetic individuals without and with prior cardiovascular disease - 10-year follow-up of the Hoorn Study [J].
Becker, A ;
Bos, G ;
de Vegt, F ;
Kostense, PJ ;
Dekker, JM ;
Nijpels, G ;
Heine, RJ ;
Bouter, LM ;
Stehouwer, CDA .
EUROPEAN HEART JOURNAL, 2003, 24 (15) :1406-1413
[5]   Diabetes and atherosclerosis - Epidemiology, pathophysiology, and management [J].
Beckman, JA ;
Creager, MA ;
Libby, P .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (19) :2570-2581
[6]  
Bjorkegren J, 1996, J LIPID RES, V37, P76
[7]   Increased ApoB in small dense LDL particles predicts premature coronary artery disease [J].
Brunzell, JD .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (03) :474-475
[8]   EVIDENCE FOR A COMMON, SATURABLE, TRIGLYCERIDE REMOVAL MECHANISM FOR CHYLOMICRONS AND VERY LOW-DENSITY LIPOPROTEINS IN MAN [J].
BRUNZELL, JD ;
HAZZARD, WR ;
PORTE, D ;
BIERMAN, EL .
JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (07) :1578-1585
[9]   15 YEAR MORTALITY IN CORONARY DRUG PROJECT PATIENTS - LONG-TERM BENEFIT WITH NIACIN [J].
CANNER, PL ;
BERGE, KG ;
WENGER, NK ;
STAMLER, J ;
FRIEDMAN, L ;
PRINEAS, RJ ;
FRIEDEWALD, W .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1986, 8 (06) :1245-1255
[10]   Critical review of acylation-stimulating protein physiology in humans and rodents [J].
Cianflone, K ;
Xia, ZN ;
Chen, LY .
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2003, 1609 (02) :127-143