The management of epilepsy in pregnancy

被引：25

作者：

Walker, S. P. ^{[1
,2
]}

Permezel, M. ^{[1
,2
]}

Berkovic, S. F. ^{[3
,4
]}

机构：

[1] Mercy Hosp Women, Dept Perinatal Med, Heidelberg, Vic 3084, Australia

[2] Univ Melbourne, Dept Obstet & Gynaecol, Parkville, Vic 3052, Australia

[3] Univ Melbourne, Dept Med, Heidelberg West, Vic, Australia

[4] Univ Melbourne, Epilepsy Res Ctr, Heidelberg West, Vic, Australia

来源：

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY | 2009年 / 116卷 / 06期

关键词：

Epilepsy; pregnancy; reproduction; POPULATION-BASED COHORT; ANTIEPILEPTIC DRUG-USE; IN-UTERO; UK-EPILEPSY; CONGENITAL-MALFORMATIONS; SEIZURE CONTROL; PHARMACOKINETIC INTERACTIONS; PRELIMINARY EXPERIENCE; ENHANCED METABOLISM; MAJOR MALFORMATIONS;

D O I：

10.1111/j.1471-0528.2009.02141.x

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

While most women with epilepsy can expect a normal pregnancy outcome, epilepsy remains a significant contributor to both maternal and perinatal morbidity. Pre-pregnancy planning must address reliable contraception and optimisation of antiepileptic drug (AED) regimens to minimise teratogenic risk while maintaining seizure control. The most recent data from the AED registries regarding malformations is presented in this review, as is the limited data on the newer AEDs and studies linking neurocognitive outcomes to AED exposure. During pregnancy, important considerations include; therapeutic drug monitoring, surveillance for obstetric complications and vigilance for seizures during the intrapartum and postpartum period.

引用

页码：758 / 767

页数：10

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