A novel microRNA signature predicts survival in liver hepatocellular carcinoma after hepatectomy

被引：28
作者：
Fu, Qiang [1 ,2 ,3 ]
Yang, Fan [4 ]
Xiang, Tengxiao [5 ]
Huai, Guoli [1 ,2 ,3 ]
Yang, Xingxing [1 ,2 ,3 ]
Wei, Liang [1 ,2 ,3 ]
Yang, Hongji [1 ,2 ,3 ]
Deng, Shaoping [1 ,2 ,3 ,6 ]
机构：
[1] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Organ Transplantat Ctr, Chengdu 610072, Sichuan, Peoples R China
[2] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Chengdu 610072, Sichuan, Peoples R China
[3] Organ Transplantat Translat Med Key Lab Sichuan P, Chengdu 610072, Sichuan, Peoples R China
[4] Women & Children Hlth Care Ctr Luoyang, Luoyang 471000, Henan, Peoples R China
[5] Peoples Hosp Changshou Chongqing, Chongqing 401220, Peoples R China
[6] Harvard Med Sch, Massachusetts Gen Hosp, Human Islet Lab, Boston, MA 02114 USA
来源：
SCIENTIFIC REPORTS | 2018年 / 8卷
基金：
中国国家自然科学基金;
关键词：
BREAST-CANCER; GASTRIC-CANCER; EXPRESSION; MIGRATION; INVASION; PROLIFERATION; METASTASIS; GENES;
D O I：
10.1038/s41598-018-26374-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Liver hepatocellular carcinoma (LIHC) is the most common type of primary liver cancer. In the current study, genome-wide miRNA-Seq and mRNA profiles in 318 LIHC patients derived from The Cancer Genome Atlas (TCGA) were analysed to identify miRNA-based signatures for LIHC prognosis with survival analysis and a semi-supervised principal components (SPC) method. A seven-miRNA signature was confirmed for overall survival (OS) prediction by comparing miRNA profiles in paired primary tumour and solid tumour normal tissues. Thereafter, a linear prognostic model that consisted of seven miRNAs was established and used to divide patients into high-and low-risk groups according to prognostic scores. Subsequent Kaplan-Meier analysis revealed that the seven-miRNA signature correlated with a good predictive clinical outcome for 5-year survival in LIHC patients. Additionally, this miRNA-based prognostic model could also be used for OS prognosis of LIHC patients in early stages, which could guide the future therapy of those patients and promote the OS rate. Moreover, the seven-miRNA signature was an independent prognostic factor. In conclusion, this signature may serve as a prognostic biomarker and guide LIHC therapy, and it could even be used as an LIHC therapeutic target in the future.
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页数：8
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