The Association Between Race/Ethnicity and Major Birth Defects in the United States, 1999-2007

被引：101

作者：

Canfield, Mark A. ^{[1
]}

Mai, Cara T. ^{[2
]}

Wang, Ying ^{[3
]}

O'Halloran, Alissa ^{[2
]}

Marengo, Lisa K. ^{[1
]}

Olney, Richard S. ^{[2
]}

Borger, Christopher L. ^{[4
]}

Rutkowski, Rachel ^{[5
]}

Fornoff, Jane ^{[6
]}

Irwin, Nila ^{[7
]}

Copeland, Glenn ^{[8
]}

Flood, Timothy J. ^{[9
]}

Meyer, Robert E. ^{[10
]}

Rickard, Russel ^{[11
]}

Alverson, C. J. ^{[2
]}

Sweatlock, Joseph ^{[12
]}

Kirby, Russell S. ^{[13
]}

机构：

[1] Texas Dept State Hlth Serv, Austin, TX 78714 USA

[2] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA

[3] New York State Dept Hlth, Albany, NY 12237 USA

[4] Massachusetts Dept Publ Hlth, Boston, MA USA

[5] Florida Dept Hlth, Tallahassee, FL USA

[6] Illinois Dept Publ Hlth, Springfield, IL 62761 USA

[7] Nebraska Dept Hlth & Human Serv, Lincoln, NE USA

[8] Michigan Dept Community Hlth, Michigan Birth Defects Registry, Lansing, MI USA

[9] Arizona Dept Hlth Serv, Phoenix, AZ 85007 USA

[10] North Carolina Birth Defects Monitoring Program, Raleigh, NC USA

[11] Colorado Dept Publ Hlth & Environm, Denver, CO USA

[12] New Jersey Dept Hlth, Trenton, NJ USA

[13] Univ S Florida, Dept Community & Family Hlth, Tampa, FL USA

来源：

AMERICAN JOURNAL OF PUBLIC HEALTH | 2014年 / 104卷 / 09期

关键词：

CONGENITAL HEART-DEFECTS; ORAL CLEFTS; DESCRIPTIVE EPIDEMIOLOGY; SPINA-BIFIDA; PREVALENCE; POPULATION; CALIFORNIA; TEXAS; MALFORMATIONS; GASTROSCHISIS;

D O I：

10.2105/AJPH.2014.302098

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objectives. We investigated the relationship between race/ethnicity and 27 major birth defects. Methods. We pooled data from 12 population-based birth defects surveillance systems in the United States that included 13.5million live births (1 of 3 of US births) from 1999 to 2007. Using Poisson regression, we calculated prevalence estimates for each birth defect and 13 racial/ethnic groupings, along with crude and adjusted prevalence ratios (aPRs). Non-Hispanic Whites served as the referent group. Results. American Indians/Alaska Natives had a significantly higher and 50% or greater prevalence for 7 conditions (aPR = 3.97; 95% confidence interval [CI] = 2.89, 5.44 for anotia or microtia); aPRs of 1.5 to 2.1 for cleft lip, trisomy 18, and encephalocele, and lower, upper, and any limb deficiency). Cubans and Asians, especially Chinese and Asian Indians, had either significantly lower or similar prevalences of these defects compared with non-Hispanic Whites, with the exception of anotia or microtia among Chinese (aPR = 2.08; 95% CI = 1.30, 3.33) and Filipinos (aPR = 1.90; 95% CI = 1.10, 3.30) and tetralogy of Fallot among Vietnamese (aPR = 1.60; 95% CI = 1.11, 2.32). Conclusions. This is the largest population-based study to our knowledge to systematically examine the prevalence of a range of major birth defects across many racial/ethnic groups, including Asian and Hispanic subgroups. The relatively high prevalence of birth defects in American Indians/Alaska Natives warrants further attention.

引用

页码：E14 / E23

页数：10

共 38 条

[1]

Aase J M, 1977, Birth Defects Orig Artic Ser, V13, P113

[2] Descriptive Epidemiology of Nonsyndromic Omphalocele in Texas, 1999-2004 [J].