Prasugrel Versus Ticagrelor in Patients With CYP2C19 Loss-of-Function Genotypes Results of a Randomized Pharmacodynamic Study in a Feasibility Investigation of Rapid Genetic Testing

被引：31

作者：

Franchi, Francesco ^{[1
]}

Rollini, Fabiana ^{[1
]}

Rivas, Jose ^{[1
]}

Rivas, Andrea ^{[1
]}

Agarwal, Malhar ^{[1
]}

Briceno, Maryuri ^{[1
]}

Wali, Mustafa ^{[1
]}

Nawaz, Ahmed ^{[1
]}

Silva, Gabriel ^{[1
]}

Shaikh, Zubair ^{[1
]}

Maailiki, Naji ^{[1
]}

Been, Latonya ^{[1
]}

Pineda, Andres M. ^{[1
]}

Suryadevara, Siva ^{[1
]}

Soffer, Daniel ^{[1
]}

Zenni, Martin M. ^{[1
]}

Bass, Theodore A. ^{[1
]}

Angiolillo, Dominick J. ^{[1
]}

机构：

[1] Univ Florida, Coll Med Jacksonville, 655 West 8th St, Jacksonville, FL 32209 USA

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2020年 / 5卷 / 05期

关键词：

genotyping; percutaneous coronary intervention; pharmacodynamics; prasugrel; ticagrelor; PERCUTANEOUS CORONARY INTERVENTION; GUIDED ANTIPLATELET THERAPY; PLATELET REACTIVITY; CLINICAL-OUTCOMES; CARDIOVASCULAR OUTCOMES; TROPICAL-ACS; CLOPIDOGREL; POLYMORPHISMS; IMPACT; RESPONSIVENESS;

D O I：

10.1016/j.jacbts.2020.02.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The feasibility of rapid genetic testing in patients undergoing percutaneous coronary intervention (PCI) and the comparison of the pharmacodynamic effects of prasugrel versus ticagrelor among carriers of cytochrome P450 2C19 loss-of-function alleles treated with PCI has been poorly explored. Rapid genetic testing using the Spartan assay was shown to be feasible and provides results in a timely fashion in a real-world setting of patients undergoing coronary angiography (n = 781). Among patients (n = 223, 28.5%), carriers of at least 1 loss-of-function allele treated with PCI (n = 65), prasugrel, and ticagrelor achieve similar levels of platelet inhibition. (A Pharmacodynamic Study Comparing Prasugrel Versus Ticagrelor in Patients Undergoing PCI With CYP2C19 Loss-of-function [NCT02065479]) (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：419 / 428

页数：10

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