Asymmetric acyloin condensation catalyzed by phenylpyruvate decarboxylase

被引：25

作者：

Guo, ZW ^{[1
]}

Goswami, A ^{[1
]}

Mirfakhrae, KD ^{[1
]}

Patel, RN ^{[1
]}

机构：

[1] Bristol Myers Squibb, Pharmaceut Res Inst, Proc Res & Dev, Proc Res,Enzyme Technol, New Brunswick, NJ 08903 USA

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(99)00548-0

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cells obtained from growth of Achromobacter eurydice, Pseudomonas aromatica and Pseudomonas putida on L-phenylalanine containing medium catalyzed the enzymatic acyloin condensation of phenylpyruvic acid 1 and acetardehyde 2 by phenylpyruvate decarboxylase to produce 3-hydroxy-1-phenyl-2-butanone 3. The acyloin condensation by Achramobacter eurydice and P. aromatica was stereoselective, providing the 3R enantiomer 3a with enantiomeric excess (ee) of 95% and 84%, respectively. A partially purified enzyme was prepared from the cell free extract of Achromobacter eyrydice. The acyloin product 3a was obtained in 45% yield with an ee of 91% by using this partially purified preparation of phenylpyruvate decarboxylase. (C) 2000 Elsevier Science Ltd. Ail rights reserved.

引用

页码：4667 / 4675

页数：9

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