Improved carbonylation of heterocyclic chlorides and electronically challenging aryl bromides

被引：79

作者：

Albaneze-Walker, J ^{[1
]}

Bazaral, C ^{[1
]}

Leavey, T ^{[1
]}

Dormer, PG ^{[1
]}

Murry, JA ^{[1
]}

机构：

[1] Merck & Co Inc, Merck Res Labs, Proc Res, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 13期

关键词：

D O I：

10.1021/ol0498287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Optimized conditions are described that effect the carbonylation of diverse heterocyclic chlorides to yield the desired alkyl esters. In addition, bromoanilines and bromoanisoles, which normally are poor substrates under standard carbonylation protocols, were efficiently converted to the desired products under these new conditions. The nature of the metal bidentate ligand complex was found to be critical. Specifically, a correlation between ligand bite angle and catalytic efficiency is documented.

引用

页码：2097 / 2100

页数：4

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