LeishMan Recommendations for Treatment of Cutaneous and Mucosal Leishmaniasis in Travelers, 2014

被引：97

作者：

Blum, Johannes ^{[1
,2
,3
]}

Buffet, Pierre ^{[4
,5
,6
]}

Visser, Leo ^{[3
,7
]}

Harms, Gundel ^{[8
]}

Bailey, Mark S. ^{[9
]}

Caumes, Eric ^{[1
,10
]}

Clerinx, Jan ^{[3
,11
]}

van Thiel, Pieter P. A. M. ^{[12
]}

Morizot, Gloria ^{[4
]}

Hatz, Christoph ^{[1
,2
,3
]}

Dorlo, Thomas P. C. ^{[13
]}

Lockwood, Diana N. J. ^{[14
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] TropNet, European Network Trop Med & Travel Hlth, Basel, Switzerland

[4] UMRs945 INSERM UPMC Immun & Infect, Paris, France

[5] Hop La Pitie Salpetriere, Serv Parasitol Mycol, Paris, France

[6] Univ Paris 06, Paris, France

[7] Leiden Univ, Med Ctr, Leiden, Netherlands

[8] Charite, Inst Trop Med & Int Hlth, D-13353 Berlin, Germany

[9] Royal Ctr Def Med, Birmingham, W Midlands, England

[10] Hop La Pitie Salpetriere, Serv Malad Infect & Trop, Paris, France

[11] Inst Trop Med, B-2000 Antwerp, Belgium

[12] Univ Amsterdam, Ctr Trop & Travel Med, Amsterdam, Netherlands

[13] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands

[14] London Sch Hyg & Trop Med, London WC1, England

来源：

JOURNAL OF TRAVEL MEDICINE | 2014年 / 21卷 / 02期

关键词：

INTRALESIONAL MEGLUMINE ANTIMONIATE; SODIUM STIBOGLUCONATE THERAPY; RANDOMIZED CLINICAL-TRIAL; LIPOSOMAL AMPHOTERICIN-B; LOCAL HEAT THERAPY; OLD-WORLD; DOUBLE-BLIND; TOPICAL TREATMENT; METHYLBENZETHONIUM CHLORIDE; MUCOCUTANEOUS LEISHMANIASIS;

D O I：

10.1111/jtm.12089

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background. Treatment of cutaneous leishmaniasis (CL) and mucosal leishmaniasis (ML) in travelers is still controversial. Over the last decade, national and international consortia have published recommendations for treating CL in travelers. These guidelines harmonize many issues, but there are some discrepancies. Methods. Leishmania parasites causing CL can now be genotyped by polymerase chain reaction techniques for detecting Leishmania DNA. Therefore, treatment recommendations can now be species based rather than based on geographical exposure. To review the evidence on which the recommendations were based, "LeishMan" (Leishmaniasis Management), a group of experts from 13 institutions in eight European countries, performed a PubMed (MEDLINE) literature search and considered unpublished evidence and the experts' own personal experiences. The Oxford evidence grading system was used to evaluate the information. Results and Conclusion. In this article, the authors provide practical treatment recommendations for imported CL and ML in Europe, drawn up from the review by the European experts.

引用

页码：116 / 129

页数：14

共 144 条

[1] Localized mucosal leishmaniasis due to Leishmania (Leishmania) infantum clinical and microbiologic findings in 31 patients [J].