rs9263726 is a specific genetic marker for allopurinol-induced severe cutaneous adverse reactions in Chinese patients

被引：5

作者：

Chen, Zhiyao ^{[1
]}

Zhang, Shichao ^{[1
,2
]}

Zhang, Jingjing ^{[1
]}

Zhang, Yan ^{[1
]}

Xue, Ling ^{[1
]}

Miao, Liyan ^{[1
]}

机构：

[1] Soochow Univ, Res Lab, Dept Clin Pharmacol, Affiliated Hosp 1, Suzhou 215006, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215006, Peoples R China

来源：

PERSONALIZED MEDICINE | 2015年 / 12卷 / 06期

基金：

中国国家自然科学基金;

关键词：

allopurinol; Chinese patients; HLA-B*58:01; rs9263726; SCARs; TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON-SYNDROME; INFLAMMATORY-BOWEL-DISEASE; DRUG-REACTIONS; HAN CHINESE; HYPERURICEMIA; GOUT; FEBUXOSTAT; GUIDELINES; MANAGEMENT;

D O I：

10.2217/pme.15.38

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: Screening of an easily detectable biomarker to replace the HLA allele B variant (HLA-B*58:01) testing for predicting allopurinol-induced severe cutaneous adverse reactions (SCARs) in eastern Chinese patients. Methods: Six SNPs and the HLA-B*58:01 were analyzed in 17 patients with allopurinol-induced SCARs and in 151 control patients. SNPs were analyzed by pyrosequencing, and HLA-B*58:01 was evaluated by sequencing-based techniques. Consistency between sequencing-based HLA-B*58:01 testing and pyrosequencing-based rs9263726 testing was investigated in 262 individuals. Results: A significant association with allopurinol-induced SCARs was found at rs9263726 (odds ratio: 108.8) and HLA-B*58:01 (odds ratio: 108.8). The kappa values between sequencing-based HLA-B*58:01 testing and pyrosequencing-based rs9263726 testing were 0.96 (>0.75), demonstrating they were well coincident with each other. Conclusion: rs9263726 was a useful surrogate of HLA-B*58:01 testing for prescreening allopurinol-induced SCARs in eastern Chinese patients.

引用

页码：585 / 592

页数：8

共 27 条

[11] Febuxostat for hyperuricemia: experience with patients on chronic hemodialysis treatment [J].

Horikoshi, Ryoko ;

Akimoto, Tetsu ;

Inoue, Makoto ;

Morishita, Yoshiyuki ;

Kusano, Eiji .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2013, 17 (01) :149-150

[12] HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol [J].

Hung, SL ;

Chung, WH ;

Liou, LB ;

Chu, CC ;

Lin, M ;

Huang, HP ;

Lin, YL ;

Lan, JL ;

Yang, LC ;

Hong, HS ;

Chen, MJ ;

Lai, PC ;

Wu, MS ;

Chu, CY ;

Wang, KH ;

Chen, CH ;

Fann, CSJ ;

Wu, JY ;

Chen, YT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (11) :4134-4139

[13] Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans [J].

Kang, Hye-Ryun ;

Jee, Young Koo ;

Kim, Yon-Soo ;

Lee, Chang Hwa ;

Jung, Jae-Woo ;

Kim, Sae Hoon ;

Park, Heung-Woo ;

Chang, Yoon-Seok ;

Jang, In-Jin ;

Cho, Sang-Heon ;

Min, Kyung-Up ;

Kim, Sang-Heon ;

Lee, Kyung Wha .

PHARMACOGENETICS AND GENOMICS, 2011, 21 (05) :303-307

[14]

Liu B, 2012, INFECT DIS OBSTET GY, V2012

[15] A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs [J].

Lonjou, Christine ;

Borot, Nicolas ;

Sekula, Peggy ;

Ledger, Neil ;

Thomas, Laure ;

Halevy, Sima ;

Naldi, Luigi ;

Bouwes-Bavinck, Jan-Nico ;

Sidoroff, Alexis ;

de Toma, Claudia ;

Schumacher, Martin ;

Roujeau, Jean-Claude ;

Hovnanian, Alain ;

Mockenhaupt, Maja .

PHARMACOGENETICS AND GENOMICS, 2008, 18 (02) :99-107

[16] Development of a Rapid and Inexpensive Assay for Detecting a Surrogate Genetic Polymorphism of HLA-B*58:01: A Partially Predictive but Useful Biomarker for Allopurinol-related Stevens-Johnson Syndrome/toxic Epidermal Necrolysis in Japanese [J].

Maekawa, Keiko ;

Nishikawa, Jun ;

Kaniwa, Nahoko ;

Sugiyama, Emiko ;

Koizumi, Tomoko ;

Kurose, Kouichi ;

Tohkin, Masahiro ;

Saito, Yoshiro .

DRUG METABOLISM AND PHARMACOKINETICS, 2012, 27 (04) :447-450

[17] Severe drug-induced skin reactions: clinical pattern, diagnostics and therapy [J].

Mockenhaupt, Maja .

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2009, 7 (02) :142-160

[18] Guidelines for the management of inflammatory bowel disease in adults [J].

Mowat, Craig ;

Cole, Andrew ;

Windsor, Al ;

Ahmad, Tariq ;

Arnott, Ian ;

Driscoll, Richard ;

Mitton, Sally ;

Orchard, Tim ;

Rutter, Matt ;

Younge, Lisa ;

Lees, Charlie ;

Ho, Gwo-tzer ;

Satsangi, Jack ;

Bloom, Stuart .

GUT, 2011, 60 (05) :571-607

[19] HLA-B*58:01 strongly associates with allopurinol-induced adverse drug reactions in a Japanese sample population [J].

Niihara, Hiroyuki ;

Kaneko, Sakae ;

Ito, Takahumi ;

Sugamori, Takashi ;

Takahashi, Nobuyuki ;

Kohno, Kunie ;

Morita, Eishin .

JOURNAL OF DERMATOLOGICAL SCIENCE, 2013, 71 (02) :150-152

[20]

Palmer Deborah, 2013, Br J Community Nurs, V18, P424

← 1 2 3 →